Stace Catherine L, Ktistakis Nicholas T
Signaling Programme, Babraham Institute, Cambridge CB2 4AT, UK.
Biochim Biophys Acta. 2006 Aug;1761(8):913-26. doi: 10.1016/j.bbalip.2006.03.006. Epub 2006 Apr 3.
Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids with well-recognized structural roles in cellular membranes. They are also signaling lipids since their regulated formation (or appearance) can constitute an important signal for downstream responses. The list of potential effectors for these lipids is expanding rapidly and includes proteins involved in virtually all aspects of cellular regulation. Because it is not always clear whether these effectors recognize the specific phospholipids or a general negatively-charged membrane environment, questions about specificity must be addressed on a case by case basis. In this review we present an up to date list of potential phosphatidic acid- and phosphatidylserine-binding proteins.
磷脂酸和磷脂酰丝氨酸是带负电荷的丰富磷脂，在细胞膜中具有公认的结构作用。它们也是信号脂质，因为其受调控的形成（或出现）可构成下游反应的重要信号。这些脂质的潜在效应分子列表正在迅速扩展，包括几乎参与细胞调节各个方面的蛋白质。由于并不总是清楚这些效应分子是识别特定的磷脂还是一般带负电荷的膜环境，因此关于特异性的问题必须逐案解决。在本综述中，我们列出了一份最新的潜在磷脂酸和磷脂酰丝氨酸结合蛋白清单。
