Sepponen K, Pösö A R
Department of Basic Veterinary Sciences, University of Helsinki, Helsinki, Finland.
Vet J. 2006 May;171(3):519-24. doi: 10.1016/j.tvjl.2005.01.005.
Modern rearing conditions may cause stress to pigs. At the cellular level all animals respond to stress by synthesizing heat shock proteins (HSP), which protect cells from injury. The objective of this study was to examine the concentrations of stress-inducible HSP72 in porcine small intestine and colon, known to be stress sensitive tissues, and to compare the findings with HSP72 concentrations in serum and with conventional markers of stress, namely blood lactate and serum cortisol, glucose, free fatty acids and acute phase proteins. HSP72 in the colon correlated with serum HSP72 but there was a negative correlation with carcass weight (growth). The results suggest that the colon may be a significant source of serum HSP72, the concentration of which may reflect changes in the permeability of intestinal epithelium due to stressors, such as transport and handling.
现代饲养条件可能会给猪造成应激。在细胞水平上，所有动物都会通过合成热休克蛋白（HSP）来应对应激，热休克蛋白可保护细胞免受损伤。本研究的目的是检测猪的小肠和结肠（已知为应激敏感组织）中应激诱导型HSP72的浓度，并将结果与血清中HSP72的浓度以及应激的传统标志物（即血乳酸、血清皮质醇、葡萄糖、游离脂肪酸和急性期蛋白）进行比较。结肠中的HSP72与血清HSP72相关，但与胴体重量（生长）呈负相关。结果表明，结肠可能是血清HSP72的重要来源，其浓度可能反映了由于运输和处理等应激源导致的肠上皮通透性变化。
