Stewart A G, Grigoriadis G
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
J Lipid Mediat. 1991 Nov;4(3):299-308.
Analogues of PAF were examined for their potency in stimulating either platelet aggregation or macrophage superoxide anion generation. Modification of either the alkyl side-chain or the acetyl side-chain increased the relative potency of PAF analogues in macrophages, but all these compounds were more active in platelets. However, an analogue of PAF with an increased inter-ionic distance in the polar head group, hexanolamine PAF, showed a greater potency in macrophages than platelets. The latter compound also appeared to act as a partial agonist in both rabbit platelets and guinea-pig macrophages, but not in guinea-pig platelets. Differences in the rank order of potency of the PAF analogues in stimulating these cell elements suggest that platelet and macrophage PAF receptors differ.
研究了血小板活化因子（PAF）类似物刺激血小板聚集或巨噬细胞超氧阴离子生成的效力。烷基侧链或乙酰基侧链的修饰提高了PAF类似物在巨噬细胞中的相对效力，但所有这些化合物在血小板中更具活性。然而，一种在极性头部基团中离子间距离增加的PAF类似物，己醇胺PAF，在巨噬细胞中的效力比在血小板中更大。后一种化合物在兔血小板和豚鼠巨噬细胞中似乎也作为部分激动剂起作用，但在豚鼠血小板中不起作用。PAF类似物刺激这些细胞成分的效力排序差异表明血小板和巨噬细胞的PAF受体不同。
