Chan S C, Birdsell D C, Gradeen C Y
Department of Laboratory Medicine, Foothills Hospital, Calgary, Alberta, Canada.
Clin Chem. 1991 Dec;37(12):2143-5.
We report the detection of free 2,4-toluenediamine in urine of a patient implanted with polyurethane-covered breast implants. Samples were collected on several dates, ranging from 21 days to seven months after the insertion of the implants, and these samples all showed the presence of free 2,4-toluenediamine at a concentration of about 1 micrograms/L. The chemical was not found in a urine sample collected before implantation. This finding is important for risk assessment of cancer in patients with this type of breast implant because the chemical is a suspected carcinogen. Free 2,6-toluenediamine, an isomer, was also found in all samples from this patient.
我们报告了一名植入聚氨酯包膜乳房植入物患者尿液中游离2,4-甲苯二胺的检测情况。在植入植入物后的21天至7个月的不同日期采集了样本，这些样本均显示存在浓度约为1微克/升的游离2,4-甲苯二胺。在植入前采集的尿液样本中未发现该化学物质。这一发现对于此类乳房植入物患者的癌症风险评估很重要，因为该化学物质是一种疑似致癌物。在该患者的所有样本中还发现了其异构体游离2,6-甲苯二胺。
