Chan S C, Birdsell D C, Gradeen C Y
Department of Laboratory Medicine, Foothills Hospital, Calgary, Alberta, Canada.
Clin Chem. 1991 May;37(5):756-8.
Breast prostheses are implanted for augmentation or during reconstructive surgery. One of the more commonly used prostheses is the polyurethane-sponge-covered silicone gel implant. Some clinicians are concerned about the safety of this product because the polyurethane foam disintegrates in vivo, and its subsequent fate is not known. Polyurethane is a polymer formed by reacting diisocyanates and polyols. This study indicates that the polymer sponge breaks down into its reactive monomers, 2,4- and 2,6-toluenediisocyanate, which are converted into their corresponding diamines. We present evidence of the excretion of the diamine metabolites in the urine of a patient implanted with polyurethane-covered prostheses.
乳房假体用于隆胸或重建手术。一种较为常用的假体是聚氨酯海绵覆盖的硅胶凝胶植入物。一些临床医生担心该产品的安全性，因为聚氨酯泡沫在体内会分解，其后续去向不明。聚氨酯是由二异氰酸酯和多元醇反应形成的聚合物。本研究表明，聚合物海绵会分解成其反应性单体2,4-和2,6-甲苯二异氰酸酯，这些单体又会转化为相应的二胺。我们提供了植入聚氨酯覆盖假体患者尿液中二胺代谢物排泄的证据。
