Gomez-Roman Natividad, Felton-Edkins Zoë A, Kenneth Niall S, Goodfellow Sarah J, Athineos Dimitris, Zhang Jingxin, Ramsbottom Ben A, Innes Fiona, Kantidakis Theodoros, Kerr Elaine R, Brodie Jacqueline, Grandori Carla, White Robert J
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK.
Biochem Soc Symp. 2006(73):141-54. doi: 10.1042/bss0730141.
The proto-oncogene product c-Myc can induce cell growth and proliferation. It regulates a large number of RNA polymerase II-transcribed genes, many of which encode ribosomal proteins, translation factors and other components of the biosynthetic apparatus. We have found that c-Myc can also activate transcription by RNA polymerases I and III, thereby stimulating production of rRNA and tRNA. As such, c-Myc may possess the unprecedented capacity to induce expression of all ribosomal components. This may explain its potent ability to drive cell growth, which depends on the accumulation of ribosomes. The activation of RNA polymerase II transcription by c-Myc is often inefficient, but its induction of rRNA and tRNA genes can be very strong in comparison. We will describe what is known about the mechanisms used by c-Myc to activate transcription by RNA polymerases I and II.
原癌基因产物c-Myc可诱导细胞生长和增殖。它调控大量由RNA聚合酶II转录的基因，其中许多基因编码核糖体蛋白、翻译因子和生物合成装置的其他组分。我们发现，c-Myc还可激活RNA聚合酶I和III的转录，从而刺激rRNA和tRNA的产生。因此，c-Myc可能具有诱导所有核糖体组分表达的前所未有的能力。这或许可以解释其驱动细胞生长的强大能力，而细胞生长依赖于核糖体的积累。c-Myc对RNA聚合酶II转录的激活通常效率不高，但与之相比，它对rRNA和tRNA基因的诱导作用可能非常强。我们将描述关于c-Myc用于激活RNA聚合酶I和II转录的机制的已知信息。
