Curtis D, Knight J, Sham P C
Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK.
Ann Hum Genet. 2006 Mar;70(Pt 2):277-9. doi: 10.1111/j.1529-8817.2005.00225.x.
We describe a suite of programs which enhance the usability of GENECOUNTING, a program for estimating haplotype frequencies in unrelated subjects. The programs, called RUNGC, SCANASSOC, COMPGR, SCANGROUP and LDPAIRS, carry out likelihood ratio tests and permutation tests to detect differences in haplotype frequencies between cases and controls,or between predefined groups, and output likely haplotype assignments and tables of linkage disequilibrium statistics between all pairs of markers in a dataset.
我们描述了一套程序，这些程序增强了GENECOUNTING的可用性，GENECOUNTING是一个用于估计非亲缘个体单倍型频率的程序。这些程序名为RUNGC、SCANASSOC、COMPGR、SCANGROUP和LDPAIRS，它们进行似然比检验和置换检验，以检测病例组与对照组之间或预定义组之间单倍型频率的差异，并输出可能的单倍型分配以及数据集中所有标记对之间的连锁不平衡统计表格。
