Lee Kwang-Hyuk, Farrow Tom F D, Parks Randolph W, Newton Lisa D, Mir Nusrat U, Egleston Paul N, Brown Wendy H, Wilkinson Iain D, Woodruff Peter W R
Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, United Kingdom.
J Psychiatr Res. 2007 Oct;41(8):645-51. doi: 10.1016/j.jpsychires.2006.03.001. Epub 2006 Apr 19.
We aimed to investigate cerebellar structural abnormalities and their functional significance in patients with schizophrenia. Forty right-handed men with schizophrenia and 40 sex, age and handedness matched controls underwent a volumetric magnetic resonance scan with 1 mm3 isotropic spatial resolution. Cerebellar grey- and white-matter volumes were analysed using voxel-based morphometry. Patients with schizophrenia completed a battery of neuropsychological tests assessing sustained attention (continuous performance test), memory (Hopkins memory test) and executive function (verbal fluency and Wisconsin card sorting tests). Patients with schizophrenia exhibited significantly increased cerebellar vermis white-matter volume compared with controls. By contrast, total cerebellar volume, and grey- and white-matter volumes of cerebellar hemispheres were not significantly different between groups. Increased vermis white-matter volume in patients was associated with poor verbal fluency performance. We concluded that increased white-matter in the cerebellar vermis, possibly suggesting anomalous connectivity, may be associated with verbal executive dysfunction in men with chronic schizophrenia.
我们旨在研究精神分裂症患者的小脑结构异常及其功能意义。40名右利手男性精神分裂症患者和40名性别、年龄和利手相匹配的对照者接受了体素磁共振扫描，空间分辨率为1立方毫米各向同性。使用基于体素的形态测量法分析小脑灰质和白质体积。精神分裂症患者完成了一系列神经心理学测试，以评估持续注意力（连续操作测试）、记忆力（霍普金斯记忆测试）和执行功能（言语流畅性和威斯康星卡片分类测试）。与对照组相比，精神分裂症患者的小脑蚓部白质体积显著增加。相比之下，两组之间的小脑总体积以及小脑半球的灰质和白质体积没有显著差异。患者蚓部白质体积增加与言语流畅性表现不佳有关。我们得出结论，小脑蚓部白质增加可能提示连接异常，这可能与慢性精神分裂症男性的言语执行功能障碍有关。
