Marchandin Hélène, Eden Aurélia, Jean-Pierre Hélène, Reynes Jacques, Jumas-Bilak Estelle, Boiron Patrick, Laurent Frédéric
Laboratoire de Bactériologie, Hôpital Arnaud de Villeneuve, 34295 Montpellier Cedex 5, France.
Diagn Microbiol Infect Dis. 2006 Jul;55(3):237-40. doi: 10.1016/j.diagmicrobio.2006.01.023. Epub 2006 Apr 19.
We describe a case of culture-negative cerebral nocardiosis in a 34-year-old immunocompetent man who presented multiple cerebral abscesses. All bacteriologic cultures were negative. Nocardiosis was diagnosed by using a direct genus-specific 16S rDNA amplification method, and Nocardia abscessus was identified by hsp65 sequence analysis. The patient is alive and well on imipenem and doxycycline therapy, 14 months after onset.
我们描述了一例34岁免疫功能正常男性的培养阴性脑诺卡菌病病例，该患者出现多处脑脓肿。所有细菌培养均为阴性。通过直接属特异性16S rDNA扩增方法诊断为诺卡菌病，并通过hsp65序列分析鉴定为脓肿诺卡菌。发病14个月后，患者在接受亚胺培南和强力霉素治疗后情况良好，仍存活。
