Liu Shanshan, Zhu Huilin, Zhang Shuwei, Zhang Xiaohui, Yu Qiang, Xuan Lijiang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, PR China.
J Nat Prod. 2008 May;71(5):755-9. doi: 10.1021/np0703489. Epub 2008 Mar 19.
Five new naturally occurring abietane diterpenoids (1-5) along with three known diterpenoids (6-8) were isolated from an acetone-soluble extract of the roots of Clerodendrum bungei. The structures of the new compounds were elucidated on the basis of spectroscopic analysis and chemical methods. In addition, all compounds were evaluated for cytotoxic activity against the cultured B16 (murine melanoma), HGC-27 (human gastric), and HEK-293 (human epithelial kidney) cell lines. Uncinatone (7) exhibited moderate cytotoxicity, inhibited cell proliferation, and induced cell-cycle G(2)/M phase arrest.
从臭牡丹根的丙酮可溶提取物中分离得到5个新的天然枞酸型二萜（1 - 5）以及3个已知二萜（6 - 8）。通过光谱分析和化学方法阐明了新化合物的结构。此外，对所有化合物针对培养的B16（小鼠黑色素瘤）、HGC - 27（人胃癌）和HEK - 293（人胚肾）细胞系进行了细胞毒性活性评估。钩状内酯（7）表现出中等细胞毒性，抑制细胞增殖，并诱导细胞周期G(2)/M期阻滞。
