Ahsan Monira, Islam S K N, Gray Alexander I, Stimson William H
Department of Pharmacy and Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh.
J Nat Prod. 2003 Jul;66(7):958-61. doi: 10.1021/np020356j.
Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.
从甜地丁地上部分分离得到4个新的半日花烷型二萜类化合物，异甜地丁醇（1）、4-表-东甜地丁酸B（2）、甜地丁二醇（4）和东甜地丁醛（5），以及2个已知二萜类化合物，甜地丁醇/东甜地丁醇（3）和东甜地二醇（6）。通过广泛的核磁共振研究确定了其结构。粗提物和纯二萜类化合物对一组6种人胃癌细胞系均显示出细胞毒性。
