Rose Stephen E, Chalk Jonathan B, Janke Andrew L, Strudwick Mark W, Windus Louisa C, Hannah Dominique E, McGrath John J, Pantelis Christos, Wood Stephen J, Mowry Bryan J
Centre for Magnetic Resonance, University of Queensland, Brisbane 4072, Australia.
Neuroimage. 2006 Aug 1;32(1):16-22. doi: 10.1016/j.neuroimage.2006.03.003. Epub 2006 Apr 19.
MRI diffusion tensor imaging (DTI), optimized for measuring the trace of the diffusion tensor, was used to investigate microstructural changes in the brains of 12 individuals with schizophrenia compared with 12 matched control subjects. To control for the effects of anatomic variation between subject groups, all participants' diffusion images were nonlinearly registered to standard anatomical space. Significant statistical differences in mean diffusivity (MD) measures between the two groups were determined on a pixel-by-pixel basis, using Gaussian random field theory. We found significantly elevated MD measures within temporal, parietal and prefrontal cortical regions in the schizophrenia group (P > 0.001), especially within the medial frontal gyrus and anterior cingulate. The dorsal medial and anterior nucleus of the thalamus, including the caudate, also exhibited significantly increased MD in the schizophrenia group (P > 0.001). This study has shown for the first time that MD measures offer an alternative strategy for investigating altered prefrontal-thalamic circuitry in schizophrenia.
磁共振成像扩散张量成像（DTI）针对测量扩散张量的迹进行了优化，用于研究12名精神分裂症患者与12名匹配的对照受试者大脑中的微观结构变化。为了控制受试者组之间解剖变异的影响，将所有参与者的扩散图像非线性配准到标准解剖空间。使用高斯随机场理论，逐像素确定两组之间平均扩散率（MD）测量值的显著统计差异。我们发现精神分裂症组颞叶、顶叶和前额叶皮质区域的MD测量值显著升高（P>0.001），尤其是在内侧额回和前扣带内。包括尾状核在内的丘脑背内侧核和前核在精神分裂症组中也表现出MD显著增加（P>0.001）。这项研究首次表明，MD测量为研究精神分裂症中前额叶-丘脑回路改变提供了一种替代策略。
