Choi Jung-Seok, Kang Do-Hyung, Kim Jae-Jin, Ha Tae-Hyun, Roh Kyu Sik, Youn Tak, Kwon Jun Soo
Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea.
Psychiatry Res. 2005 Aug 30;139(3):239-47. doi: 10.1016/j.pscychresns.2004.05.008.
The anterior cingulate gyrus is a heterogeneous region that has specialized subdivisions with respect to its cytoarchitecture, function and connectivity. The aim of this study was to examine the morphological changes of the caudal subdivision of the anterior cingulate gyrus in the context of the cortico-striatal-thalamo-cortical circuitry of schizophrenia and their relationship to clinical symptoms. Accordingly, we measured the volumes of the caudal and rostral anterior cingulate gyrus, the orbitofrontal cortex, the caudate and the thalamus by magnetic resonance imaging in age- and sex-matched groups, which consisted of 22 patients with schizophrenia and 22 normal volunteers. The clinical symptoms of schizophrenia patients were obtained using the Positive and Negative Syndrome Scale. Volumetric reduction of the right caudal anterior cingulate gyrus was observed in patients with schizophrenia as compared with the normal controls. Furthermore, a smaller volume of the caudal anterior cingulate gyrus was significantly correlated with more severe positive symptoms of schizophrenia. Thus, these findings suggest that a volumetric abnormality of the caudal anterior cingulate gyrus in schizophrenia may be related to positive symptoms and possibly involved in the pathophysiology of schizophrenia.
前扣带回是一个异质性区域，在细胞结构、功能和连接性方面具有专门的细分。本研究的目的是在精神分裂症的皮质-纹状体-丘脑-皮质环路背景下，研究前扣带回尾部细分的形态学变化及其与临床症状的关系。因此，我们通过磁共振成像测量了年龄和性别匹配组中前扣带回尾部和头部、眶额皮质、尾状核和丘脑的体积，该组包括22例精神分裂症患者和22名正常志愿者。使用阳性和阴性症状量表获取精神分裂症患者的临床症状。与正常对照组相比，精神分裂症患者右侧前扣带回尾部体积减小。此外，前扣带回尾部体积较小与精神分裂症更严重的阳性症状显著相关。因此，这些发现表明，精神分裂症患者前扣带回尾部的体积异常可能与阳性症状有关，并可能参与了精神分裂症的病理生理学过程。
