Ruhland Carmen, Koschke Mandy, Greiner Wolf, Peupelmann Jeannine, Pietsch Uta, Hocke Michael, Yeragani Vikram K, Bär Karl-Jürgen
Department of Psychiatry, Friedrich-Schiller-University, Jena, Germany.
J Affect Disord. 2008 Sep;110(1-2):185-90. doi: 10.1016/j.jad.2007.12.236. Epub 2008 Mar 4.
Depressed patients frequently complain about vegetative symptoms. The aim of the present study was to evaluate gastric electrical activity in patients suffering from major depression in relation to their symptoms.
Electrogastrography (EGG) was performed before and after a test meal ingestion in 21 patients suffering from major depression and control subjects. A structured interview was used to assess the severity of clinical as well as abdominal symptoms.
Patients presented with significantly elevated proportions of tachygastria. Significant differences were found for the parameter arrhythmia, the coefficient of dominant frequency and slow wave after the test meal ingestion. A positive correlation was found between tachygastria and ANS score as well as tachygastria and the item "sweating".
Further studies are warranted to include more patients and to investigate interaction with specific antidepressive drugs.
This is the first study demonstrating an increased amount of tachygastria in patients suffering from major depression which might be caused by increased sympathetic modulation. The correlation of tachygastria with the amount of gastric symptoms underlines the clinical significance of this finding.
抑郁症患者经常抱怨出现植物神经症状。本研究的目的是评估重度抑郁症患者的胃电活动与其症状之间的关系。
对21例重度抑郁症患者和对照受试者在摄入试验餐前后进行了胃电图（EGG）检查。采用结构化访谈评估临床症状和腹部症状的严重程度。
患者出现心动过速比例显著升高。在摄入试验餐后，发现心律失常参数、主导频率系数和慢波存在显著差异。心动过速与自主神经评分以及心动过速与“出汗”项目之间存在正相关。
有必要进行进一步研究，纳入更多患者，并研究与特定抗抑郁药物的相互作用。
这是第一项证明重度抑郁症患者心动过速数量增加的研究，这可能是由交感神经调节增加所致。心动过速与胃部症状数量的相关性强调了这一发现的临床意义。
