Enzan K, Mitsuhata H, Tagawa M, Hayashi K, Ohsumi K, Yamazaki Y, Suzuki M
Department of Anesthesiology, Akita University School of Medicine.
Masui. 1991 Nov;40(11):1632-5.
To investigate whether prostaglandin E1 (PGE1) 30 ng.kg-1.min-1 inhibits the release of lysosomal enzyme from granulocytes by surgical stimuli, we measured myeloperoxidase and alpha 1-protease inhibitor (alpha 1-PI) in 32 patients for head neck surgery. The patients were divided into two groups; no PGE1 infusion group (C group) and PGE1 30 ng.kg-1.min-1 infusion group (P group). PGE1 was infused intravenously using a syringe pump during operation. MPO and alpha 1-PI were measured at 4 points: before induction of anesthesia, before surgery, 4 hours after the start of surgery or the infusion of PGE1, and on the first postoperative day. MPO was maintained at significantly higher levels during and after surgery in both groups. alpha 1-PI decreased significantly during operation and increased for 10% in the first postoperative day in both groups. There were no significant differences between groups in MPO and alpha 1-PI levels. We conclude that the infusion of PGE1 30 ng.kg-1.min-1 did not completely inhibit the release of lysosomal enzyme from granulocytes by surgical stimuli.
为研究前列腺素E1（PGE1）30 ng·kg-1·min-1是否能抑制手术刺激引起的粒细胞溶酶体酶释放，我们对32例接受头颈手术的患者测定了髓过氧化物酶和α1-蛋白酶抑制剂（α1-PI）。患者被分为两组：未输注PGE1组（C组）和输注PGE1 30 ng·kg-1·min-1组（P组）。手术期间使用注射泵静脉输注PGE1。在4个时间点测定MPO和α1-PI：麻醉诱导前、手术前、手术开始或输注PGE1后4小时以及术后第一天。两组在手术期间及术后MPO均维持在显著较高水平。两组在手术期间α1-PI均显著降低，且在术后第一天均升高10%。两组间MPO和α1-PI水平无显著差异。我们得出结论，输注30 ng·kg-1·min-1的PGE1不能完全抑制手术刺激引起的粒细胞溶酶体酶释放。
