Enzan K, Mitsuhata H, Yamazaki Y, Suzuki M
Department of Anesthesiology, Akita University School of Medicine.
Masui. 1991 Aug;40(8):1187-92.
We studied whether prostaglandin E1 (PGE1) inhibits the granulocyte elastase increase, white blood cell increase and platelet decrease caused by surgical stimuli in 30 head-neck surgical patients. The patients were divided into a group of no PGE1 infusion (C group) and two groups of PGE1 infusion (infusion of 10 ng.kg-1.min-1 in P 10 group and infusion of 30 ng.kg-1.min-1 in P 30 group). PGE1 was infused intravenously using a syringe pump during operation. The granulocyte elastase, white blood cells and platelets were measured at 4 points: before induction of anesthesia, before surgery, 4 hours after the start of surgery or the infusion of PGE1, and on the first postoperative day. Granulocyte elastase was maintained at significantly higher levels during and after surgery in 3 groups. White blood cells correlated with granulocyte elastase in 3 groups (especially in C group; Granulocyte elastase = 1.48 X white blood cells + 23.5, r = 0.672). Platelets decreased significantly in the first postoperative day in C and P 10 group. PGE1 has a tendency to inhibit dose-dependently the postoperative decrease in platelets. We conclude that 30 ng.kg-1.min-1 infusion of PGE1 did not inhibit granulocyte elastase release from white blood cells, but has a tendency to inhibit postoperative platelet decrease.
我们研究了前列腺素E1（PGE1）是否能抑制30例头颈外科手术患者因手术刺激引起的粒细胞弹性蛋白酶增加、白细胞增加和血小板减少。患者被分为未输注PGE1的一组（C组）和两组输注PGE1的组（P10组输注10 ng·kg-1·min-1，P30组输注30 ng·kg-1·min-1）。手术期间使用注射泵静脉输注PGE1。在4个时间点测量粒细胞弹性蛋白酶、白细胞和血小板：麻醉诱导前、手术前、手术开始或输注PGE1后4小时以及术后第一天。三组患者在手术期间及术后粒细胞弹性蛋白酶水平均显著升高。三组患者白细胞与粒细胞弹性蛋白酶相关（尤其是C组；粒细胞弹性蛋白酶=1.48×白细胞+23.5，r=0.672）。C组和P10组术后第一天血小板显著减少。PGE1有剂量依赖性抑制术后血小板减少的趋势。我们得出结论，输注30 ng·kg-1·min-1的PGE1不能抑制白细胞释放粒细胞弹性蛋白酶，但有抑制术后血小板减少的趋势。
