Sartori Maria Salete, Aragon Flávio Ferrari, Padovani Carlos Roberto, Pimenta Walkyria de P
Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, UNESP, Botucatu, SP.
Arq Bras Endocrinol Metabol. 2006 Feb;50(1):53-9. doi: 10.1590/s0004-27302006000100008. Epub 2006 Apr 17.
Epidemiological studies have documented that postprandial hyperglycemia is the main risk factor for cardiovascular diseases. It has been established that glycated hemoglobin (HbA1C) provides an integrated measure of plasma glucose (PG) of the last 2-3 months. However, the relative contribution of fasting PG (FPG) and postprandial PG (PPG) to the HbA1C value is controversial.
To evaluate FPG and PPG contributions to the HbA1C value in patients with type 2 diabetes mellitus (DM2).
53 subjects with stable DM2 were studied. They were treated with oral anti-diabetic agents (n = 27) and/or insulin (n = 26). Each subject went to 3 visits at 2-month-intervals. On each visit, FPG, PPG (2 h after breakfast and lunch), and HbA1C were measured and we provided breakfast and lunch according to their meal habits. PG was measured by glucose-oxidase and HbA1C by ion-exchange chromatography. Statistical analysis was performed by correlation coefficients at a < 0.05 P value.
Correlations were stronger between HbA1C and post-breakfast PG (r: 0.66-0.48), mean FPG (r: 0.64-0.41), glucose area under the curve (r: 0.64-0.46), and mean PPG (r: 0.59-0.41).
Measurement of post-breakfast PG showed to be another valuable tool for type 2 diabetic glucose control monitoring.
流行病学研究已证明餐后高血糖是心血管疾病的主要危险因素。糖化血红蛋白（HbA1C）已被确定为过去2至3个月血浆葡萄糖（PG）的综合指标。然而，空腹血糖（FPG）和餐后血糖（PPG）对HbA1C值的相对贡献仍存在争议。
评估2型糖尿病（DM2）患者中FPG和PPG对HbA1C值的贡献。
对53例病情稳定的DM2患者进行研究。他们接受口服降糖药（n = 27）和/或胰岛素（n = 26）治疗。每位受试者每隔2个月进行3次就诊。每次就诊时，测量FPG、PPG（早餐和午餐后2小时）和HbA1C，并根据他们的饮食习惯提供早餐和午餐。PG采用葡萄糖氧化酶法测量，HbA1C采用离子交换色谱法测量。采用相关系数进行统计分析，P值<0.05。
HbA1C与早餐后PG（r：0.66 - 0.48）、平均FPG（r：0.64 - 0.41）、曲线下葡萄糖面积（r：0.64 - 0.46）和平均PPG（r：0.59 - 0.41）之间的相关性更强。
测量早餐后PG是监测2型糖尿病血糖控制的另一种有价值的工具。
