Schneider Kathrin, Nicholson Graeme, Ströbele Markus, Baur Stephanie, Niehaus Jörg, Fiedler Hans-Peter, Süssmuth Roderich D
Institut für Organische Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, D-10623 Berlin, Germany.
J Antibiot (Tokyo). 2006 Feb;59(2):105-9. doi: 10.1038/ja.2006.15.
Three new fluostatin antibiotics have been isolated from the culture filtrate of Streptomyces strain Acta 1383. The chemical structures of these compounds were determined by mass spectrometry and NMR spectroscopy. The relative configuration has been determined by X-ray crystal structure analysis and the absolute configuration was deduced from NMR data with the help of Helmchen esters. These compounds represent the first reported epoxide fluostatins (1, 2) and underline previously found analogies to the group of kinamycin antibiotics.
从链霉菌Acta 1383菌株的培养滤液中分离出了三种新型氟他汀抗生素。通过质谱和核磁共振光谱确定了这些化合物的化学结构。通过X射线晶体结构分析确定了相对构型，并借助赫尔姆兴酯从核磁共振数据推导出绝对构型。这些化合物是首次报道的环氧化氟他汀（1, 2），并突出了先前发现的与奇那霉素类抗生素的相似之处。
