Graf Ellen, Schneider Kathrin, Nicholson Graeme, Ströbele Markus, Jones Amanda L, Goodfellow Michael, Beil Winfried, Süssmuth Roderich D, Fiedler Hans-Peter
Institut für Chemie, Technische Universität Berlin.
J Antibiot (Tokyo). 2007 Apr;60(4):277-84. doi: 10.1038/ja.2007.35.
Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
从灰色链霉菌Acta 2871的培养滤液中分离出两种具有抗肿瘤活性的新型氨基酚嗪酮化合物，即咯嗪酮A和B。通过质谱、核磁共振光谱和X射线分析确定了它们的化学结构。咯嗪酮A和B在体外对人胃腺癌细胞的增殖有中度抑制作用，但对肝癌细胞有强烈抑制作用，而咯嗪酮B强烈抑制人乳腺癌细胞的增殖。
