Sepulcre J, Vanotti S, Hernández R, Sandoval G, Cáceres F, Garcea O, Villoslada P
Department of Neurology, Multiple Sclerosis Centre, Clinica Universitaria, University of Navarra, Spain.
Mult Scler. 2006 Apr;12(2):187-95. doi: 10.1191/1352458506ms1258oa.
To assess the cognitive impairment of multiple sclerosis (MS) patients using the Brief Repeatable Battery-Neuropsychology (BRB-N) test.
The performance of 59 patients with MS in the BRB-N test was assessed and compared with 152 matched healthy controls (HC).
In most tests, MS patients performed worse than controls. Age and educational level strongly influenced the performance of the subjects. The Symbol Digit Modality Test (SDMT) best correlated with the other individual tests and contributed most to the general BRB-N factor. Furthermore, a correlation between physical disability and performance in some BRB-N tests was observed. Indeed, patients with progressive MS and greater physical disability performed worse in some tests than less disabled patients with relapsing MS. By creating a global BRB-N Z score, we found that patients generally performed 0.7 standard deviation (SD) below the level of controls. We obtained cut-off values stratified by age and education to determinate cognitive impairment in MS patients.
Our data show that cognitive impairment is prevalent amongst MS patients, and that a single cognitive measurement might be useful for monitoring patients during the progression of this illness.
使用简易重复性成套神经心理学测验（BRB-N）评估多发性硬化症（MS）患者的认知障碍。
评估了59例MS患者在BRB-N测验中的表现，并与152名匹配的健康对照者（HC）进行比较。
在大多数测验中，MS患者的表现比对照者差。年龄和教育水平对受试者的表现有强烈影响。符号数字模式测验（SDMT）与其他单项测验的相关性最好，对总体BRB-N因子的贡献最大。此外，观察到身体残疾与某些BRB-N测验表现之间存在相关性。确实，进行性MS且身体残疾程度较高的患者在某些测验中的表现比复发型MS且残疾程度较轻的患者差。通过创建总体BRB-N Z评分，我们发现患者的总体表现比对照者低0.7个标准差（SD）。我们获得了按年龄和教育程度分层的临界值，以确定MS患者的认知障碍。
我们的数据表明，认知障碍在MS患者中很普遍，并且单一的认知测量可能有助于在这种疾病的进展过程中监测患者。
