Fölster-Holst R, Pape M, Buss Y L, Christophers E, Weichenthal M
Department of Dermatology, University Hospital of Schleswig-Holstein, University of Kiel, Kiel, Germany.
Allergy. 2006 May;61(5):629-32. doi: 10.1111/j.1398-9995.2006.01076.x.
Atopic dermatitis (AD) is a chronic inflammatory skin disease commonly associated with respiratory allergies such as rhinitis and asthma, and a high serum level of IgE. In contrast to the 'classic' IgE-mediated allergic (extrinsic) form of AD, approximately 20% of the patients are reported to show normal IgE levels, lack of sensitizations towards environmental allergens, and absence of associated respiratory allergies. Accordingly, these patients are assigned to a nonallergic (intrinsic) form of the disease.
In order to define these two forms of AD more closely, 259 adult patients with AD were investigated.
After a thorough diagnostic workup there were 18 patients (6.9%), who fulfilled the criteria of intrinsic AD. After follow-up, four additional patients had developed respiratory allergies or IgE-mediated sensitizations resulting in an overall proportion for intrinsic AD of 5.4%.
Based on these figures the nature and relevance of the intrinsic form of AD deserves further evaluation.
特应性皮炎（AD）是一种慢性炎症性皮肤病，通常与鼻炎和哮喘等呼吸道过敏以及血清IgE水平升高有关。与“经典”的IgE介导的过敏性（外源性）AD形式不同，据报道约20%的患者IgE水平正常，对环境过敏原无致敏反应，且无相关呼吸道过敏。因此，这些患者被归类为非过敏性（内源性）疾病形式。
为了更确切地定义这两种AD形式，对259例成年AD患者进行了研究。
经过全面的诊断检查，有18例患者（6.9%）符合内源性AD的标准。随访后，又有4例患者出现呼吸道过敏或IgE介导的致敏反应，导致内源性AD的总体比例为5.4%。
基于这些数据，AD内源性形式的性质和相关性值得进一步评估。
