Marcovina S, Packard C J
Department of Medicine, University of Washington, Seattle, WA, USA.
J Intern Med. 2006 May;259(5):437-46. doi: 10.1111/j.1365-2796.2006.01648.x.
Apolipoproteins AI and B are structural components of lipoprotein particles, and also determinants of the metabolic fate of the encapsulated lipid, cholesterol and triglyceride. Development of accurate assays for these apolipoproteins has opened the way for their use as predictors of coronary heart disease risk. Interpretation of AI and apo B levels is best undertaken with background knowledge of the metabolic status of an individual, especially the lipolytic capacity as reflected in the triglyceride concentration. Those with raised triglyceride, in general, not only have an elevated apo B/apo AI ratio, but also apo B-containing lipoproteins with a prolonged residence time and hence ample opportunity for modification and damage. Assessment of apolipoprotein levels is an aid to risk prediction and can be useful in tailoring treatment.
载脂蛋白AI和B是脂蛋白颗粒的结构成分，也是包封的脂质、胆固醇和甘油三酯代谢命运的决定因素。针对这些载脂蛋白的准确检测方法的开发，为将其用作冠心病风险预测指标开辟了道路。对AI和载脂蛋白B水平的解读，最好结合个体代谢状况的背景知识进行，尤其是甘油三酯浓度所反映的脂解能力。一般来说，甘油三酯升高的人不仅载脂蛋白B/载脂蛋白AI比值升高，而且含载脂蛋白B的脂蛋白停留时间延长，因此有充分机会发生修饰和损伤。载脂蛋白水平的评估有助于风险预测，并且在调整治疗方案方面可能有用。
