Liu J, Takeda T, Dogan I, Bhargava V, Mittal R K
Division of Gastroenterology, University of California, San Diego and San Diego VA HealthCare System, San Diego, CA 92161, USA.
Neurogastroenterol Motil. 2006 May;18(5):376-84. doi: 10.1111/j.1365-2982.2006.00763.x.
Relaxation and opening of the oesophago-gastric junction (OGJ) is crucial for oesophageal transport. A novel ultrasound technique was used to determine OGJ opening, before and after atropine, in 12 normals. An ultrasound probe, a solid-state pressure transducer and an infusion tube were placed inside a 20-mm diameter bag, which was placed across the OGJ. At various bag pressures ultrasound transducer was pulled across the bag. Acquired B-mode ultrasound images were converted into M-mode image to display the oesophagus, OGJ and stomach. At low bag-pressure (< 20 mmHg), the OGJ but not oesophagus and stomach, is collapsed around the bag. Increasing bag pressure results in gradual opening of the OGJ from distal end. M-mode image identified the narrowest region of OGJ and corresponding cross-sectional area (CSA) was measured. Mean bag pressure to initial OGJ opening was 18 mmHg. Linear relationship between bag-pressure and OGJ-CSA was observed. Atropine reduced opening bag pressure and shifted the OGJ pressure-CSA curve upward without altering slope, i.e. compliance. Our novel ultrasound technique to study the OGJ opening function shows two distinct components; firstly, related to the tonic OGJ contraction and secondly, to passive or viscoelastic properties of the OGJ.
食管胃交界处（OGJ）的松弛和开放对食管运输至关重要。采用一种新型超声技术，在12名正常人中测定了阿托品给药前后OGJ的开放情况。将一个超声探头、一个固态压力传感器和一根输液管置于一个直径20毫米的袋子内，该袋子横跨OGJ放置。在不同的袋子压力下，将超声换能器拉过袋子。采集的B型超声图像转换为M型图像以显示食管、OGJ和胃。在低袋子压力（<20 mmHg）时，OGJ而非食管和胃在袋子周围塌陷。增加袋子压力会导致OGJ从远端逐渐开放。M型图像确定了OGJ最狭窄区域并测量了相应的横截面积（CSA）。OGJ初始开放时的平均袋子压力为18 mmHg。观察到袋子压力与OGJ-CSA之间呈线性关系。阿托品降低了开放袋子压力，并使OGJ压力-CSA曲线向上移动，而斜率即顺应性未改变。我们用于研究OGJ开放功能的新型超声技术显示出两个不同的组成部分；首先，与OGJ的张力性收缩有关，其次，与OGJ的被动或粘弹性特性有关。
