Song G, Hou X, Yang B, Sun Y, Liu J, Qian W, Chen J D Z
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Neurogastroenterol Motil. 2006 May;18(5):385-91. doi: 10.1111/j.1365-2982.2006.00758.x.
The aim of this study was to determine the most effective and efficient anti-emetic parameters of short-pulse gastric electrical stimulation (GES) in dogs. Seven female beagle dogs implanted with four pairs of gastric electrodes were studied in eight randomized sessions (saline, vasopressin, and six GES sessions with different parameters). Each session consisted of four 20-min recordings of gastric slow waves and symptoms. In sessions 1 and 2, saline and vasopressin, respectively, were infused during the second 20-min period. The protocol of the other six sessions was the same as session 2 except that GES was continuously applied. It was found that: (1) vasopressin induced gastric dysrhythmia and emetic response (P < 0.01, anova); (2) short-pulse GES with a frequency of 14 or 40 Hz and pulse width of 0.1 or 0.3 ms, but not 0.6 ms was able to reduce symptoms induced by vasopressin; (3) short-pulse GES with a pulse width of 0.3 ms was the most effective in preventing vasopressin-induced symptoms; (4) none of the tested GES methods improved vasopressin-induced gastric dysrhythmia. We conclude that vasopressin induces gastric dysrhythmia and symptoms. Short-pulse GES with a pulse width of 0.3 ms and frequency of 14 Hz is most effective and efficient in preventing vasopressin-induced emetic responses in dogs.
本研究的目的是确定短脉冲胃电刺激（GES）对犬最有效和高效的抗呕吐参数。对7只植入了四对胃电极的雌性比格犬进行了8次随机试验（生理盐水、血管加压素以及6次不同参数的GES试验）。每次试验包括4次20分钟的胃慢波和症状记录。在第1次和第2次试验中，分别在第二个20分钟期间输注生理盐水和血管加压素。其他6次试验的方案与第2次试验相同，只是持续施加GES。结果发现：（1）血管加压素诱发胃节律失常和呕吐反应（P<0.01，方差分析）；（2）频率为14或40Hz、脉冲宽度为0.1或0.3ms而非0.6ms的短脉冲GES能够减轻血管加压素诱发的症状；（3）脉冲宽度为0.3ms的短脉冲GES在预防血管加压素诱发的症状方面最有效；（4）所测试的GES方法均未改善血管加压素诱发的胃节律失常。我们得出结论，血管加压素诱发胃节律失常和症状。脉冲宽度为0.3ms、频率为14Hz的短脉冲GES在预防犬血管加压素诱发的呕吐反应方面最有效且高效。
