一种新型双脉冲胃电刺激方法对胃节律紊乱以及恶心和呕吐症状的治疗潜力。
Therapeutic potentials of a novel method of dual-pulse gastric electrical stimulation for gastric dysrhythmia and symptoms of nausea and vomiting.
作者信息
Liu Jinsong, Qiao Xian, Chen Jiande D Z
机构信息
Division of Gastroenterology, University of Texas Medical Branch, GI Research, Route 0632, Room 221, Microbiology Building, 1108 The Strand, Galveston, TX 77555-0632, USA.
出版信息
Am J Surg. 2006 Feb;191(2):255-61. doi: 10.1016/j.amjsurg.2005.11.005.
BACKGROUND
The aims of this study were to investigate the effects and mechanisms of a novel method of gastric electrical stimulation on the prevention of vasopressin-induced emetic response and gastric dysrhythmias.
METHODS
Fifteen dogs (10 normal, 5 vagotomized) chronically implanted with gastric serosal electrodes were used in a 3-session study (vasopressin, vasopressin plus 2-channel stimulation [DCS], and vasopressin plus dual-pulse stimulation [DPS]).
RESULTS
Vasopressin induced gastric dysrhythmias and motion sickness-like symptoms (P < .05) and these effects were blocked partially with vagotomy. Both methods of DCS and DPS were capable of preventing vasopressin-induced gastric dysrhythmias (P < .05) and motion sickness-like symptoms (P < .05). The antiemetic effects of the proposed methods of DCS and DPS were abolished by vagotomy but their antidysrhythmic effects were not blocked by vagotomy.
CONCLUSIONS
DCS and DPS are able to reduce vasopressin-induced gastric dysrhythmia and symptoms of nausea and vomiting. The vagal pathway is involved in the antiemetic effect but not the antidysrhythmic effect of the proposed methods of stimulation.
背景
本研究旨在探讨一种新型胃电刺激方法对预防血管加压素诱导的呕吐反应和胃节律紊乱的作用及机制。
方法
15只慢性植入胃浆膜电极的犬（10只正常犬，5只迷走神经切断犬）用于一项分三个阶段的研究（血管加压素、血管加压素加双通道刺激[DCS]、血管加压素加双脉冲刺激[DPS]）。
结果
血管加压素诱导胃节律紊乱和晕动病样症状（P <.05），迷走神经切断可部分阻断这些效应。DCS和DPS两种方法均能预防血管加压素诱导的胃节律紊乱（P <.05）和晕动病样症状（P <.05）。DCS和DPS方法的止吐作用可被迷走神经切断消除，但其抗心律失常作用不受迷走神经切断的影响。
结论
DCS和DPS能够减轻血管加压素诱导的胃节律紊乱以及恶心和呕吐症状。迷走神经通路参与了所提出的刺激方法的止吐作用，但不参与其抗心律失常作用。
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