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本文引用的文献

1
Efficacy and efficiency of gastric electrical stimulation with short pulses in the treatment of vasopressin-induced emetic responses in dogs.短脉冲胃电刺激对犬血管加压素诱导呕吐反应的疗效和效率
Neurogastroenterol Motil. 2006 May;18(5):385-91. doi: 10.1111/j.1365-2982.2006.00758.x.
2
Efficiency and efficacy of multi-channel gastric electrical stimulation.多通道胃电刺激的效率与疗效
Neurogastroenterol Motil. 2005 Dec;17(6):878-82. doi: 10.1111/j.1365-2982.2005.00688.x.
3
Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin.双通道胃电刺激可加速由血管加压素引起的胃排空延迟。
Dig Dis Sci. 2005 Apr;50(4):662-8. doi: 10.1007/s10620-005-2553-5.
4
Effects of vasopressin and long pulse-low frequency gastric electrical stimulation on gastric emptying, gastric and intestinal myoelectrical activity and symptoms in dogs.血管加压素和长脉冲-低频胃电刺激对犬胃排空、胃肠肌电活动及症状的影响
Neurogastroenterol Motil. 2005 Apr;17(2):236-44. doi: 10.1111/j.1365-2982.2004.00616.x.
5
American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis.美国胃肠病学会关于胃轻瘫诊断与治疗的技术审查
Gastroenterology. 2004 Nov;127(5):1592-622. doi: 10.1053/j.gastro.2004.09.055.
6
Vagal afferent is involved in short-pulse gastric electrical stimulation in rats.迷走神经传入纤维参与大鼠短脉冲胃电刺激过程。
Dig Dis Sci. 2004 May;49(5):729-37. doi: 10.1023/b:ddas.0000030081.91006.86.
7
Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long-term follow-up.胃电刺激治疗胃轻瘫可在短期、中期和长期随访中改善营养参数。
JPEN J Parenter Enteral Nutr. 2003 Jul-Aug;27(4):277-81. doi: 10.1177/0148607103027004277.
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Gastric electrical stimulation for medically refractory gastroparesis.胃电刺激治疗难治性胃轻瘫。
Gastroenterology. 2003 Aug;125(2):421-8. doi: 10.1016/s0016-5085(03)00878-3.
9
Gastric electrical stimulation with short pulses reduces vomiting but not dysrhythmias in dogs.短脉冲胃电刺激可减少犬类呕吐，但不能减少心律失常。
Gastroenterology. 2003 Feb;124(2):401-9. doi: 10.1053/gast.2003.50048.
10
Gastric emptying in diabetes: clinical significance and treatment.糖尿病患者的胃排空：临床意义与治疗
Diabet Med. 2002 Mar;19(3):177-94. doi: 10.1046/j.1464-5491.2002.00658.x.

一种新型的双通道双脉冲胃电刺激方法可改善犬的固体胃排空。

A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs.

作者信息

Song Geng-Qing, Hou Xiaohua, Yang Bin, Sun Yan, Qian Wei, Chen J D Z

机构信息

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

出版信息

Surgery. 2008 Jan;143(1):72-8. doi: 10.1016/j.surg.2007.07.001. Epub 2007 Dec 3.

DOI:10.1016/j.surg.2007.07.001
PMID:18154935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2677293/
Abstract

BACKGROUND

Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses.

METHODS

Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses.

RESULTS

(1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).

CONCLUSIONS

The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.

摘要

背景

已知胃电刺激（GES）通过短脉冲改善呕吐，通过长脉冲使心律失常正常化，并通过双通道加速胃排空。本研究的目的是评估一种新的GES方法，即双脉冲双通道GES对固体食物胃排空、胃节律紊乱和催吐反应的影响。

方法

对7只植入4对电极的比格犬进行研究。提出了一种新的GES方法：双通道双脉冲GES，其中每个刺激由一个短脉冲后跟一个长脉冲组成，并在2个不同位置进行刺激。进行该研究以测试这种新的GES方法对血管加压素诱导的固体食物胃排空延迟、胃节律紊乱和催吐反应的影响。

结果

（1）血管加压素诱导胃节律紊乱和催吐反应，以及固体食物胃排空延迟（P <.01）。（2）双通道而非单通道双脉冲GES能够加速血管加压素诱导的固体食物胃排空延迟。（3）单通道和双通道双脉冲GES均能改善节律紊乱和催吐反应（P <.01）。

结论

双通道双脉冲GES新方法能够加速固体食物胃排空，并改善血管加压素诱导的节律紊乱和催吐反应。这种新的GES方法可能对胃轻瘫具有潜在应用价值。