Suppr超能文献

一种新型的双通道双脉冲胃电刺激方法可改善犬的固体胃排空。

A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs.

作者信息

Song Geng-Qing, Hou Xiaohua, Yang Bin, Sun Yan, Qian Wei, Chen J D Z

机构信息

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

出版信息

Surgery. 2008 Jan;143(1):72-8. doi: 10.1016/j.surg.2007.07.001. Epub 2007 Dec 3.

DOI:10.1016/j.surg.2007.07.001
PMID:18154935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2677293/
Abstract

BACKGROUND

Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses.

METHODS

Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses.

RESULTS

(1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).

CONCLUSIONS

The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.

摘要

背景

已知胃电刺激（GES）通过短脉冲改善呕吐，通过长脉冲使心律失常正常化，并通过双通道加速胃排空。本研究的目的是评估一种新的GES方法，即双脉冲双通道GES对固体食物胃排空、胃节律紊乱和催吐反应的影响。

方法

对7只植入4对电极的比格犬进行研究。提出了一种新的GES方法：双通道双脉冲GES，其中每个刺激由一个短脉冲后跟一个长脉冲组成，并在2个不同位置进行刺激。进行该研究以测试这种新的GES方法对血管加压素诱导的固体食物胃排空延迟、胃节律紊乱和催吐反应的影响。

结果

（1）血管加压素诱导胃节律紊乱和催吐反应，以及固体食物胃排空延迟（P <.01）。（2）双通道而非单通道双脉冲GES能够加速血管加压素诱导的固体食物胃排空延迟。（3）单通道和双通道双脉冲GES均能改善节律紊乱和催吐反应（P <.01）。

结论

双通道双脉冲GES新方法能够加速固体食物胃排空，并改善血管加压素诱导的节律紊乱和催吐反应。这种新的GES方法可能对胃轻瘫具有潜在应用价值。

相似文献

1
A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs.
Surgery. 2008 Jan;143(1):72-8. doi: 10.1016/j.surg.2007.07.001. Epub 2007 Dec 3.
2
Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin.
Dig Dis Sci. 2005 Apr;50(4):662-8. doi: 10.1007/s10620-005-2553-5.
3
Effects of vasopressin and long pulse-low frequency gastric electrical stimulation on gastric emptying, gastric and intestinal myoelectrical activity and symptoms in dogs.
Neurogastroenterol Motil. 2005 Apr;17(2):236-44. doi: 10.1111/j.1365-2982.2004.00616.x.
4
Efficacy and efficiency of gastric electrical stimulation with short pulses in the treatment of vasopressin-induced emetic responses in dogs.
Neurogastroenterol Motil. 2006 May;18(5):385-91. doi: 10.1111/j.1365-2982.2006.00758.x.
5
Effects of gastric electrical stimulation with short pulses and long pulses on gastric dysrhythmia and signs induced by vasopressin in dogs.
Dig Dis Sci. 2008 Mar;53(3):630-5. doi: 10.1007/s10620-007-9918-x. Epub 2007 Aug 25.
6
Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs.
Dig Liver Dis. 2009 Apr;41(4):277-82. doi: 10.1016/j.dld.2008.07.312. Epub 2008 Sep 16.
7
Effects of intestinal electrical stimulation on intestinal dysrhythmia and symptoms in dogs.
Dig Dis Sci. 2004 May;49(5):720-8. doi: 10.1023/b:ddas.0000030080.60168.01.
8
Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs.
Am J Surg. 2008 Jan;195(1):122-9. doi: 10.1016/j.amjsurg.2007.04.007.
9
Efficiency and efficacy of multi-channel gastric electrical stimulation.
Neurogastroenterol Motil. 2005 Dec;17(6):878-82. doi: 10.1111/j.1365-2982.2005.00688.x.
10
Effect of two-channel gastric electrical stimulation with trains of pulses on gastric motility.
World J Gastroenterol. 2009 May 21;15(19):2406-11. doi: 10.3748/wjg.15.2406.

引用本文的文献

1
Roux-en-Y duodenojejunostomy improves gastric emptying in experimental obstruction of the distal duodenum.
PLoS One. 2018 Jun 28;13(6):e0199759. doi: 10.1371/journal.pone.0199759. eCollection 2018.
2
Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew.
Neurogastroenterol Motil. 2016 Aug;28(8):1217-32. doi: 10.1111/nmo.12821. Epub 2016 Apr 12.
3
Long-term effects of gastric stimulation on gastric electrical physiology.
J Gastrointest Surg. 2013 Jan;17(1):50-5; discussion p.55-6. doi: 10.1007/s11605-012-2020-5. Epub 2012 Sep 7.
4
Gastroparesis: pathogenesis, diagnosis and management.
Nat Rev Gastroenterol Hepatol. 2011 Jul 19;8(8):438-53. doi: 10.1038/nrgastro.2011.116.
5
Gastric electrical stimulation for gastroparesis: a goal greatly pursued, but not yet attained.
World J Gastroenterol. 2011 Jan 21;17(3):273-82. doi: 10.3748/wjg.v17.i3.273.
6
Effect of two-channel gastric electrical stimulation with trains of pulses on gastric motility.
World J Gastroenterol. 2009 May 21;15(19):2406-11. doi: 10.3748/wjg.15.2406.
7
Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs.
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G310-8. doi: 10.1152/ajpgi.90525.2008. Epub 2008 Nov 20.

本文引用的文献

1
Efficacy and efficiency of gastric electrical stimulation with short pulses in the treatment of vasopressin-induced emetic responses in dogs.
Neurogastroenterol Motil. 2006 May;18(5):385-91. doi: 10.1111/j.1365-2982.2006.00758.x.
2
Efficiency and efficacy of multi-channel gastric electrical stimulation.
Neurogastroenterol Motil. 2005 Dec;17(6):878-82. doi: 10.1111/j.1365-2982.2005.00688.x.
3
Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin.
Dig Dis Sci. 2005 Apr;50(4):662-8. doi: 10.1007/s10620-005-2553-5.
4
Effects of vasopressin and long pulse-low frequency gastric electrical stimulation on gastric emptying, gastric and intestinal myoelectrical activity and symptoms in dogs.
Neurogastroenterol Motil. 2005 Apr;17(2):236-44. doi: 10.1111/j.1365-2982.2004.00616.x.
5
American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesis.
Gastroenterology. 2004 Nov;127(5):1592-622. doi: 10.1053/j.gastro.2004.09.055.
6
Vagal afferent is involved in short-pulse gastric electrical stimulation in rats.
Dig Dis Sci. 2004 May;49(5):729-37. doi: 10.1023/b:ddas.0000030081.91006.86.
7
Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long-term follow-up.
JPEN J Parenter Enteral Nutr. 2003 Jul-Aug;27(4):277-81. doi: 10.1177/0148607103027004277.
8
Gastric electrical stimulation for medically refractory gastroparesis.
Gastroenterology. 2003 Aug;125(2):421-8. doi: 10.1016/s0016-5085(03)00878-3.
9
Gastric electrical stimulation with short pulses reduces vomiting but not dysrhythmias in dogs.
Gastroenterology. 2003 Feb;124(2):401-9. doi: 10.1053/gast.2003.50048.
10
Gastric emptying in diabetes: clinical significance and treatment.
Diabet Med. 2002 Mar;19(3):177-94. doi: 10.1046/j.1464-5491.2002.00658.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验