一种新型的双通道双脉冲胃电刺激方法可改善犬的固体胃排空。
A novel method of 2-channel dual-pulse gastric electrical stimulation improves solid gastric emptying in dogs.
作者信息
Song Geng-Qing, Hou Xiaohua, Yang Bin, Sun Yan, Qian Wei, Chen J D Z
机构信息
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
出版信息
Surgery. 2008 Jan;143(1):72-8. doi: 10.1016/j.surg.2007.07.001. Epub 2007 Dec 3.
BACKGROUND
Gastric electrical stimulation (GES) is known to improve vomiting with short pulses, normalize dysrhythmia with long pulses, and accelerate gastric emptying with 2 channels. The aim of this study was to assess the effects of a new method GES, namely, 2-channel GES with dual pulses on gastric emptying of solids as well as gastric dysrhythmia and emetic responses.
METHODS
Seven beagle dogs implanted with 4 pairs of electrodes were studied. A novel method of GES was proposed: 2-channel dual-pulse GES in which each stimulus was composed of a short pulse followed with a long pulse, and stimulation was delivered at 2 different locations. The study was performed to test the effects of this new method of GES on vasopressin-induced delayed gastric emptying of solids, gastric dysrhythmia, and emetic responses.
RESULTS
(1) Vasopressin-induced gastric dysrhythmia and emetic responses, as well as delayed gastric emptying of solids (P < .01). (2) Two-channel, but not 1-channel, dual-pulse GES was able to accelerate vasopressin-induced delayed gastric emptying of solids. (3) Both 1- and 2-channel dual-pulse GES was capable of improving dysrhythmia and emetic responses (P < .01).
CONCLUSIONS
The novel method of 2-channel dual-pulse GES is capable of accelerating gastric emptying of solids and improving dysrhythmia and emetic responses induced by vasopressin. This new method of GES may have a potential for gastroparesis.
背景
已知胃电刺激（GES）通过短脉冲改善呕吐，通过长脉冲使心律失常正常化，并通过双通道加速胃排空。本研究的目的是评估一种新的GES方法，即双脉冲双通道GES对固体食物胃排空、胃节律紊乱和催吐反应的影响。
方法
对7只植入4对电极的比格犬进行研究。提出了一种新的GES方法：双通道双脉冲GES，其中每个刺激由一个短脉冲后跟一个长脉冲组成，并在2个不同位置进行刺激。进行该研究以测试这种新的GES方法对血管加压素诱导的固体食物胃排空延迟、胃节律紊乱和催吐反应的影响。
结果
（1）血管加压素诱导胃节律紊乱和催吐反应，以及固体食物胃排空延迟（P <.01）。（2）双通道而非单通道双脉冲GES能够加速血管加压素诱导的固体食物胃排空延迟。（3）单通道和双通道双脉冲GES均能改善节律紊乱和催吐反应（P <.01）。
结论
双通道双脉冲GES新方法能够加速固体食物胃排空，并改善血管加压素诱导的节律紊乱和催吐反应。这种新的GES方法可能对胃轻瘫具有潜在应用价值。
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