Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway.
Department of Occupational Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
Nutrients. 2022 Apr 4;14(7):1506. doi: 10.3390/nu14071506.
In a recent study we found that fathers' but not mothers' onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring's adult lung function, a key marker of general and respiratory health, has not been studied. We investigated the potential causal effects of parents' overweight on adult offspring's lung function within the paternal and maternal lines. We included 929 offspring (aged 18-54, 54% daughters) of 308 fathers and 388 mothers (aged 40-66). Counterfactual-based multi-group mediation analyses by offspring's sex (potential moderator) were used, with offspring's prepubertal overweight and/or adult height as potential mediators. Unknown confounding was addressed by simulation analyses. Fathers' overweight before puberty had a negative indirect effect, mediated through sons' height, on sons' forced expiratory volume in one second (FEV) (beta (95% CI): -144 (-272, -23) mL) and forced vital capacity (FVC) (beta (95% CI): -210 (-380, -34) mL), and a negative direct effect on sons' FVC (beta (95% CI): -262 (-501, -9) mL); statistically significant effects on FEV/FVC were not observed. Mothers' overweight before puberty had neither direct nor indirect effects on offspring's lung function. Fathers' overweight starting before puberty appears to cause lower FEV and FVC in their future sons. The effects were partly mediated through sons' adult height but not through sons' prepubertal overweight.
在最近的一项研究中，我们发现父亲而不是母亲在青春期超重与成年后代哮喘有关。父母超重对后代成年肺功能的潜在影响（一般和呼吸健康的关键标志）尚未得到研究。我们在父系和母系内调查了父母超重对成年后代肺功能的潜在因果影响。我们纳入了 308 名父亲和 388 名母亲（年龄 40-66 岁）的 929 名后代（年龄 18-54 岁，54%为女性）。通过后代的性别（潜在的调节因素）进行了基于反事实的多组中介分析，将后代的青春期前超重和/或成年身高作为潜在的中介因素。通过模拟分析解决了未知的混杂因素。青春期前超重的父亲通过儿子的身高对儿子的一秒用力呼气容积（FEV）（β（95%置信区间）：-144（-272，-23）mL）和用力肺活量（FVC）（β（95%置信区间）：-210（-380，-34）mL）有负间接影响，对儿子的 FVC 有负直接影响（β（95%置信区间）：-262（-501，-9）mL）；未观察到对 FEV/FVC 的统计学显著影响。青春期前超重的母亲对后代的肺功能没有直接或间接影响。青春期前超重的父亲似乎会导致他们未来的儿子的 FEV 和 FVC 降低。这些影响部分通过儿子的成年身高介导，但不是通过儿子的青春期前超重。
