Park Hyun-Ho, Ha Eunyoung, Uhm Yoon Kyung, Jin Sheng-Yu, Kim Youn-Jung, Chung Joo-Ho, Lee Mu-Hyoung
Department of Dermatology, College of Medicine, Kyunghee University, Seoul, Republic of Korea.
Exp Dermatol. 2006 May;15(5):377-80. doi: 10.1111/j.0906-6705.2006.00423.x.
Vitiligo is an acquired pigmentary disorder characterized by well-circumscribed depigmented patches. Autoimmune, self-destruction, neural, and genetic theories have been proposed for the pathogenesis of vitiligo. Reactive oxygen species play an important role in the physiology of cell damage, and catalase is known to regulate oxidative stress. Reduced catalase enzyme activity and accumulation of excessive hydrogen peroxide were observed in vitiligo. To examine whether catalase gene polymorphisms are associated with vitiligo patients in Korean population, we investigated two CAT gene polymorphisms including (T/C) BstX I (A/T) Hinf I in 118 vitiligo patients and 200 healthy volunteers. The CAT gene genotype distribution and allele frequency were not significantly different between vitiligo patients and healthy controls. But, the haplotype of two polymorphisms was associated with vitiligo. This study suggests possible association between the CAT gene and the vitiligo susceptibility.
白癜风是一种后天性色素沉着紊乱疾病，其特征为界限清晰的色素脱失斑。关于白癜风的发病机制，已提出自身免疫、自我破坏、神经和遗传等理论。活性氧在细胞损伤生理过程中起重要作用，已知过氧化氢酶可调节氧化应激。在白癜风患者中观察到过氧化氢酶活性降低和过量过氧化氢积累。为研究过氧化氢酶基因多态性是否与韩国人群中的白癜风患者相关，我们调查了118例白癜风患者和200名健康志愿者的两种CAT基因多态性，包括（T/C）BstX I和（A/T）Hinf I。白癜风患者与健康对照之间的CAT基因基因型分布和等位基因频率无显著差异。但是，两种多态性的单倍型与白癜风相关。本研究提示CAT基因与白癜风易感性之间可能存在关联。
