Uhm Yoon Kyung, Yoon Seo Hyun, Kang Ik Joon, Chung Joo-Ho, Yim Sung-Vin, Lee Mu-Hyoung
Kohwang Medical Research Institute, Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Korea.
Life Sci. 2007 Jun 27;81(3):223-7. doi: 10.1016/j.lfs.2007.05.006. Epub 2007 May 21.
Vitiligo is an acquired pigmentary disorder of the skin involving melanocyte dysfunction. It has been reported that melanocyte impairment could be related to increased oxidative stress. The glutathione S-transferases (GSTs) are group of polymorphic enzymes that are important in protection against oxidative stress. To find the relationship between GSTM1 and GSTT1 polymorphisms with vitiligo susceptibility, GSTM1 and GSTT1 (homozygous deletion vs. non-deleted) polymorphisms between vitiligo patients (n=310) and healthy controls (n=549) were analyzed. We observed significant association in null alleles of the GSTM1 (P<0.001, OR=2.048, 95% CI=1.529-2.743). GSTM1 null type was also statistically different between two vitiligo subtypes and controls (Focal P<0.001, OR=2.224, 95% CI=1.499-3.298; Generalized P=0.001, OR=1.974, 95% CI=1.342-2.904). However, no significant association in GSTT1 (P=0.869, OR=1.024, 95% CI=0.775-1.353) was observed with vitiligo. In combined analysis of GSTM1 and GSTT1, both null type and GSTM1/GSTT1 (null/present) group showed significant differences between controls and vitiligo patients. These results suggest that GSTM1 null type might be associated with vitiligo susceptibility in Korean population.
白癜风是一种获得性皮肤色素沉着障碍性疾病，涉及黑素细胞功能障碍。据报道，黑素细胞损伤可能与氧化应激增加有关。谷胱甘肽S-转移酶（GSTs）是一组多态性酶，在抵御氧化应激方面具有重要作用。为了探讨GSTM1和GSTT1基因多态性与白癜风易感性之间的关系，分析了白癜风患者（n = 310）和健康对照者（n = 549）之间GSTM1和GSTT1（纯合缺失与非缺失）基因多态性。我们观察到GSTM1无效等位基因存在显著关联（P<0.001，OR = 2.048，95%CI = 1.529 - 2.743）。GSTM1无效型在两种白癜风亚型与对照之间也存在统计学差异（局限性白癜风P<0.001，OR = 2.224，95%CI = 1.499 - 3.298；泛发性白癜风P = 0.001，OR = 1.974，95%CI = 1.342 - 2.904）。然而，未观察到GSTT1与白癜风有显著关联（P = 0.869，OR = 1.024，95%CI = 0.775 - 1.353）。在GSTM1和GSTT1的联合分析中，无效型以及GSTM1/GSTT1（无效/存在）组在对照与白癜风患者之间均显示出显著差异。这些结果表明，在韩国人群中，GSTM1无效型可能与白癜风易感性相关。
