ISAba1在鲍曼不动杆菌中OXA碳青霉烯酶基因表达中的作用。
The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii.
作者信息
Turton Jane F, Ward M Elaina, Woodford Neil, Kaufmann Mary E, Pike Rachel, Livermore David M, Pitt Tyrone L
机构信息
Laboratory of HealthCare Associated Infection, Centre for Infections, Health Protection Agency, London, UK.
出版信息
FEMS Microbiol Lett. 2006 May;258(1):72-7. doi: 10.1111/j.1574-6968.2006.00195.x.
ISAba1 was found in all widespread clones of Acinetobacter baumannii in the United Kingdom. All isolates studied had a blaOXA-51-like carbapenemase gene; some also had blaOXA-23-like and/or blaOXA-58-like. Among isolates with blaOXA-51-like as sole carbapenemase gene, only those with ISAba1 adjacent to blaOXA-51-like were carbapenem resistant. Minor differences in blaOXA-51-like sequence were observed in resistant and susceptible isolates. Isolates with blaOXA-23-like in addition were consistently resistant to carbapenems; in all of these ISAba1 lay upstream of blaOXA-23-like, but was not associated with blaOXA-51-like. These results suggest that ISAba1 is providing the promoter for blaOXA-51-like and, probably, for blaOXA-23-like.
在英国，鲍曼不动杆菌的所有广泛传播的克隆株中均发现了ISAba1。所有研究的分离株都有一个blaOXA - 51样碳青霉烯酶基因；有些还具有blaOXA - 23样和/或blaOXA - 58样基因。在以blaOXA - 51样作为唯一碳青霉烯酶基因的分离株中，只有那些blaOXA - 51样基因旁边有ISAba1的分离株对碳青霉烯类耐药。在耐药和敏感分离株中观察到blaOXA - 51样序列存在微小差异。此外，带有blaOXA - 23样基因的分离株始终对碳青霉烯类耐药；在所有这些分离株中，ISAba1位于blaOXA - 23样基因的上游，但与blaOXA - 51样基因无关。这些结果表明，ISAba1为blaOXA - 51样基因，可能也为blaOXA - 23样基因提供启动子。
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