Robinson C Max, Oxley Jon D, Weir Justin, Eveson John W
Department of Oral and Dental Science, University of Bristol, Bristol, UK.
J Oral Pathol Med. 2006 May;35(5):262-7. doi: 10.1111/j.1600-0714.2006.00419.x.
The presence of lichenoid or granulomatous inflammation in an oral mucosal biopsy usually suggests a distinct range of diagnostic possibilities. However, the presence of both patterns of inflammation in the same biopsy is uncommon.
A clinico-pathological study of six patients.
All the patients in this study presented with similar mucosal lesions of the upper lip. Microscopically the lesions were characterized by the presence of lichenoid inflammation with concomitant granulomatous inflammation. The lesions were persistent and refractory to treatment with steroid medications, but remained localized and did not appear to herald the onset of systemic inflammatory or neoplastic disease.
We propose the designation 'lichenoid and granulomatous stomatitis' for the cases described in this study. The clinico-pathological features of a subset of these cases suggest an unusual drug eruption.
口腔黏膜活检中出现苔藓样或肉芽肿性炎症通常提示一系列不同的诊断可能性。然而，同一活检中同时出现这两种炎症模式并不常见。
对6例患者进行临床病理研究。
本研究中的所有患者均表现为上唇类似的黏膜病变。显微镜下，病变的特征是存在苔藓样炎症并伴有肉芽肿性炎症。病变持续存在，对类固醇药物治疗无效，但仍局限于局部，似乎并未预示全身性炎症或肿瘤性疾病的发生。
我们建议将本研究中描述的病例命名为“苔藓样和肉芽肿性口炎”。这些病例中的一部分的临床病理特征提示一种不寻常的药疹。
