Oral Medicine and Pathology Unit, Department of Stomatology II, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain.
Department of Oral Medicine, Institut Claudius Regaud, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France.
BMC Oral Health. 2022 May 11;22(1):173. doi: 10.1186/s12903-022-02189-z.
Non-infectious granulomatous disorders of the upper lip represent a special chapter of oral and maxillofacial pathology. In this work we report a case-series of this process, to analyse its main clinicopathological features and find differential data that allow us improve its diagnosis and understand its pathogenesis.
We present 11 cases of non-infectious granulomatous disorders of the upper lip, 8 women and 3 men with an age range of 29-84 years, who have been attended at the Oral Medicine Department of the IUCT (France) and the Oral Medicine Unit of the UPV/EHU (Spain). All clinicopathological data were collected in a specific protocol.
We recognized 4 different subtypes of non-infectious granulomatous disorders of the upper lip: (1) associated with Crohn's disease (1 case), (2) associated with foreign body (2 cases), (3) associated with gingivitis lichenoid-like (4 cases), (4) idiopathic (4 cases).
Clinicopathological differences were identified between these subtypes. A good differential diagnosis is necessary in all cases to rule out the presence of local or systemic etiopathogenic factors.
上唇非传染性肉芽肿性疾病是口腔颌面病理学的一个特殊篇章。在这项工作中，我们报告了一系列此类病例，旨在分析其主要的临床病理特征，并找到有助于提高诊断和理解发病机制的鉴别数据。
我们展示了 11 例上唇非传染性肉芽肿性疾病，患者为 8 名女性和 3 名男性，年龄 29-84 岁，均在法国的 IUCT（法国）口腔医学系和 UPV/EHU（西班牙）口腔医学科就诊。所有临床病理数据均按照特定方案收集。
我们识别出 4 种不同类型的上唇非传染性肉芽肿性疾病：（1）与克罗恩病相关（1 例），（2）与异物相关（2 例），（3）与类似牙龈病损的类扁平苔藓相关（4 例），（4）特发性（4 例）。
这些亚型之间存在临床病理差异。在所有病例中，均需要进行良好的鉴别诊断，以排除局部或全身病因。
