上唇非感染性肉芽肿性疾病：11 例患者的临床病理分析。
Non-infectious granulomatous disorders of the upper lip: clinicopathological analysis of 11 patients.
机构信息
Oral Medicine and Pathology Unit, Department of Stomatology II, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940, Leioa, Spain.
Department of Oral Medicine, Institut Claudius Regaud, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France.
出版信息
BMC Oral Health. 2022 May 11;22(1):173. doi: 10.1186/s12903-022-02189-z.
BACKGROUND
Non-infectious granulomatous disorders of the upper lip represent a special chapter of oral and maxillofacial pathology. In this work we report a case-series of this process, to analyse its main clinicopathological features and find differential data that allow us improve its diagnosis and understand its pathogenesis.
METHODS
We present 11 cases of non-infectious granulomatous disorders of the upper lip, 8 women and 3 men with an age range of 29-84 years, who have been attended at the Oral Medicine Department of the IUCT (France) and the Oral Medicine Unit of the UPV/EHU (Spain). All clinicopathological data were collected in a specific protocol.
RESULTS
We recognized 4 different subtypes of non-infectious granulomatous disorders of the upper lip: (1) associated with Crohn's disease (1 case), (2) associated with foreign body (2 cases), (3) associated with gingivitis lichenoid-like (4 cases), (4) idiopathic (4 cases).
CONCLUSIONS
Clinicopathological differences were identified between these subtypes. A good differential diagnosis is necessary in all cases to rule out the presence of local or systemic etiopathogenic factors.
背景
上唇非传染性肉芽肿性疾病是口腔颌面病理学的一个特殊篇章。在这项工作中，我们报告了一系列此类病例，旨在分析其主要的临床病理特征，并找到有助于提高诊断和理解发病机制的鉴别数据。
方法
我们展示了 11 例上唇非传染性肉芽肿性疾病，患者为 8 名女性和 3 名男性，年龄 29-84 岁，均在法国的 IUCT（法国）口腔医学系和 UPV/EHU（西班牙）口腔医学科就诊。所有临床病理数据均按照特定方案收集。
结果
我们识别出 4 种不同类型的上唇非传染性肉芽肿性疾病：（1）与克罗恩病相关（1 例），（2）与异物相关（2 例），（3）与类似牙龈病损的类扁平苔藓相关（4 例），（4）特发性（4 例）。
结论
这些亚型之间存在临床病理差异。在所有病例中，均需要进行良好的鉴别诊断，以排除局部或全身病因。
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