Caquard M, Parlier G, Siret D
Service de Réanimation Pédiatrique, Hôpital Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex, France.
Arch Pediatr. 2006 May;13(5):453-5. doi: 10.1016/j.arcped.2006.02.012. Epub 2006 Apr 21.
This article presents the clinical observation of 2 cases of children suffering from Kawasaki disease in the same family at a 7-year interval. This observation suggests a genetic predisposition to the disease. Epidemiological surveys conducted in Japan for some years point to a genetic factor but without proof. Childhood systemic febrile vasculitis is hard to recognise, so its diagnosis is often made lately, while there is an effective therapy, which prevents from serious cardiovascular complications. Identification of its precise cause, a necessary step before any diagnostic laboratory test, will be a major breakthrough.
本文介绍了同一家庭中相隔7年先后患川崎病的2例儿童的临床观察情况。该观察结果提示该病可能存在遗传易感性。日本多年来进行的流行病学调查表明存在遗传因素，但尚无证据。儿童系统性发热性血管炎难以识别，因此其诊断往往较晚，而目前有有效的治疗方法可预防严重的心血管并发症。确定其确切病因是任何诊断性实验室检查之前的必要步骤，这将是一个重大突破。
