Trojer Patrick, Reinberg Danny
Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.
Cell. 2006 Apr 21;125(2):213-7. doi: 10.1016/j.cell.2006.04.003.
Methylation marks on the lysine residues of histone proteins are thought to contribute to epigenetic phenomena in part because of their apparent irreversibility. Will this view change with the recent discovery of histone lysine demethylases that reversibly remove methyl marks?
组蛋白赖氨酸残基上的甲基化标记被认为部分促成了表观遗传现象，这部分是因为它们明显具有不可逆性。随着最近组蛋白赖氨酸去甲基化酶的发现，这种观点会改变吗？这些酶能够可逆地去除甲基标记。
