Zhao Siyu, Zheng Jia, Yue Songkai, Chen Xiaoyang, Dong Yonghui
Department of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
J Inflamm Res. 2025 Jun 17;18:7893-7906. doi: 10.2147/JIR.S514599. eCollection 2025.
Osteoarthritis (OA) is a complex, progressive, and age-associated disease characterized by aberrant epigenetic expression. Epigenetic analysis has helped clarify the role of histone post-translational modifications (PTMs) in OA. PTMs affect histone structure and function and, therefore, regulate the expression of genes implicated in various biological processes. The roles of histone methylation and acetylation in OA progression-including extracellular collagen degradation and matrix destruction-have been thoroughly analyzed. Though several studies have shown that histone PTMs are related to OA, summative investigations in this area are lacking. The present literature review examines the relationships between histone PTMs and OA. It focuses mainly on methylation, acetylation, phosphorylation, lactylation, ubiquitination, and the roles of the histone methyltransferase (HMT)/histone demethylase (HDMT) and histone acetyltransferase (HAT)/histone deacetylase (HDAC) families in OA development. We used epigenetic tools for discovering new OA treatments. This review offers new perspectives for future studies on OA pathogenesis and treatment.
骨关节炎（OA）是一种复杂的、进行性的、与年龄相关的疾病，其特征在于异常的表观遗传表达。表观遗传分析有助于阐明组蛋白翻译后修饰（PTM）在OA中的作用。PTM影响组蛋白的结构和功能，因此调节参与各种生物学过程的基因的表达。组蛋白甲基化和乙酰化在OA进展中的作用，包括细胞外胶原蛋白降解和基质破坏，已经得到了深入分析。尽管有几项研究表明组蛋白PTM与OA有关，但该领域缺乏总结性研究。本文献综述探讨了组蛋白PTM与OA之间的关系。它主要关注甲基化、乙酰化、磷酸化、乳酰化、泛素化，以及组蛋白甲基转移酶（HMT）/组蛋白去甲基化酶（HDMT）和组蛋白乙酰转移酶（HAT）/组蛋白脱乙酰酶（HDAC）家族在OA发展中的作用。我们使用表观遗传工具来发现新的OA治疗方法。这篇综述为未来关于OA发病机制和治疗的研究提供了新的视角。
