Huberman Andrew D
Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA.
Neuron. 2006 Apr 20;50(2):175-7. doi: 10.1016/j.neuron.2006.04.006.
Spontaneous retinal activity is necessary to establish and maintain eye-specific projections to the LGN, but whether the spatial and temporal structure of this activity is important remains unclear. A new study by Demas et al. in the current issue of Neuron shows that when the frequency of spontaneous retinal waves is increased and waves abnormally persist past eye opening, eye-specific projections to the LGN desegregate. These results provide important new insight into the mechanisms that drive eye-specific refinement and stabilization.
自发视网膜活动对于建立和维持向外侧膝状体的眼特异性投射是必要的，但这种活动的时空结构是否重要仍不清楚。德马斯等人在本期《神经元》杂志上发表的一项新研究表明，当自发视网膜波的频率增加且波在睁眼后异常持续存在时，向外侧膝状体的眼特异性投射会分离。这些结果为驱动眼特异性精细化和稳定化的机制提供了重要的新见解。
