Torborg Christine L, Hansen Kristi A, Feller Marla B
Neurobiology Section, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA.
Nat Neurosci. 2005 Jan;8(1):72-8. doi: 10.1038/nn1376. Epub 2004 Dec 19.
Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in several mutant mice with differing levels of eye-specific segregation, we show that the presence of high-frequency bursts synchronized across neighboring retinal ganglion cells correlates with robust eye-specific segregation and that the presence of high levels of asynchronous spikes does not inhibit this segregation. These findings provide a possible resolution to previously described discrepancies regarding the role of retinal waves in retinogeniculate segregation.
视网膜波的阻断会阻止视网膜神经节细胞传入纤维在视觉丘脑的眼优势层中进行分离。然而,驱动这种精细化过程的视网膜波的关键特征仍存在争议。一些对视网膜波的操控会导致正常的眼优势分离,而另一些则不会。通过比较几只具有不同眼优势分离水平的突变小鼠的视网膜放电模式,我们发现相邻视网膜神经节细胞间同步的高频爆发的存在与强大的眼优势分离相关,并且高水平异步尖峰的存在并不会抑制这种分离。这些发现为先前描述的关于视网膜波在视网膜神经节细胞-丘脑分离中作用的差异提供了一种可能的解决方案。