增殖细胞核抗原的可逆性单泛素化：调控跨损伤DNA合成的新视角
Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis.
作者信息
Friedberg Errol C
机构信息
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
出版信息
Mol Cell. 2006 Apr 21;22(2):150-2. doi: 10.1016/j.molcel.2006.04.002.
PMID:16630883
Abstract
Deubiquitination of monoubiquitinated proteins is effected by a large number of deubiquitinating enzymes (DUBs) that function as cysteine proteases in eukaryotic cells. Huang et al. (2006) report the regulation of monoubiquitination of PCNA by autocleavage of a DUB called USP1 in cells exposed to UV radiation.
摘要
单泛素化蛋白的去泛素化由大量去泛素化酶（DUBs）完成，这些酶在真核细胞中作为半胱氨酸蛋白酶发挥作用。黄等人（2006年）报道，在暴露于紫外线辐射的细胞中，一种名为USP1的DUB通过自身切割来调节PCNA的单泛素化。
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