Kaur Deepinder, Rajagopalan Subramanian, Chinta Shankar, Kumar Jyothi, Di Monte Donato, Cherny Robert A, Andersen Julie K
Buck Institute for Research in Aging, Novato, CA 94945, USA.
Brain Res. 2007 Apr 6;1140:188-94. doi: 10.1016/j.brainres.2006.03.006. Epub 2006 May 2.
Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dopamine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases.
一些实验室报告称，在帕金森病（PD）所累及的脑区黑质（SN）中会出现铁蛋白升高，但这种升高是否与该疾病相关的神经退行性变存在因果关系尚不清楚。在此，我们报告中脑含多巴胺神经元中的慢性铁蛋白升高会导致这些细胞出现与年龄相关的进行性神经退行性变。这提供了强有力的证据，表明慢性铁蛋白过载可能直接参与了如帕金森病及其他相关疾病中出现的与年龄相关的神经退行性变。
