Loh H C, Tang P Y, Tee S F, Chow T J, Cheah Y C, Singh S S J
Department of Chemical Engineering, Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Setapak, Kuala Lumpur, Malaysia.
Genet Mol Res. 2012 Mar 22;11(1):725-30. doi: 10.4238/2012.March.22.2.
A number of studies have pointed to the association of BDNF (brain-derived neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) with schizophrenia. The purpose of this study was to determine whether these two genes are involved in the pathogenesis of schizophrenia in the Malay population. Two single nucleotide polymorphisms Val66Met of BDNF, -2036C>G and g.1238delG of DARPP-32 were genotyped in the Malay population in 200 patients with schizophrenia and 256 healthy controls. Analysis of allele and genotype frequencies in these two groups revealed no significant association of BDNF or DARPP-32 polymorphisms with schizophrenia in Malays. This is the first such association study in the Malay population.
多项研究指出脑源性神经营养因子（BDNF）和多巴胺与环磷腺苷调节的磷蛋白32kDa （DARPP - 32）与精神分裂症有关联。本研究的目的是确定这两个基因是否参与马来西亚人群中精神分裂症的发病机制。在200例精神分裂症患者和256名健康对照的马来西亚人群中，对BDNF的两个单核苷酸多态性Val66Met、DARPP - 32的 - 2036C>G和g.1238delG进行基因分型。对这两组等位基因和基因型频率的分析显示，在马来西亚人中，BDNF或DARPP - 32多态性与精神分裂症无显著关联。这是在马来西亚人群中首次进行的此类关联研究。
