Wong Ricky W K, Rabie A Bakr M
Department of Orthodontics, University of Hong Kong, Prince Philip Dental Hospital, Sai Ying Pun, Hong Kong.
J Oral Maxillofac Surg. 2006 May;64(5):770-7. doi: 10.1016/j.joms.2006.01.008.
We compared the amount of new bone produced by Gusuibu in collagen grafts to that produced by bone grafts and collagen grafts.
Twenty bone defects were created in the parietal bone of 14 New Zealand White rabbits. In the experimental group, 5 defects were grafted with Gusuibu extract mixed with absorbable collagen sponge, and 5 defects were grafted with autogenous endochondral bone. In the control groups, 5 defects were grafted with absorbable collagen sponge alone (active control) and 5 were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histologic assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 150 sections using image analysis.
A total of 24% and 90% more new bone were present in defects grafted with Gusuibu in collagen grafts than those grafted with bone and collagen, respectively. No bone was formed in the passive control group.
Gusuibu in collagen grafts have the effect of increased new bone formation locally and can be used as a bone graft material.
我们比较了骨碎补在胶原移植物中产生的新骨量与骨移植物和胶原移植物产生的新骨量。
在14只新西兰白兔的顶骨上制造20个骨缺损。实验组中，5个缺损用骨碎补提取物与可吸收胶原海绵混合移植，5个缺损用自体软骨内骨移植。在对照组中，5个缺损仅用可吸收胶原海绵移植（阳性对照），5个缺损不做处理（阴性对照）。在第14天处死动物，解剖缺损部位并进行组织学评估。对每个缺损部位制作连续切片。使用图像分析对150张切片进行新骨形成的定量分析。
胶原移植物中含骨碎补的缺损部位新骨量分别比骨移植物和胶原移植物的缺损部位多24%和90%。阴性对照组未形成骨组织。
胶原移植物中的骨碎补具有局部增加新骨形成的作用，可作为一种骨移植材料。
