Mkrtchyan G M, Boyajyan A S, Ayvazyan A A, Beglaryan A A
Institute of Molecular Biology of Armenian National Academy of Sciences, 7 Hasratyan St., 375014, Yerevan, Armenia.
Clin Biochem. 2006 Jul;39(7):688-91. doi: 10.1016/j.clinbiochem.2006.02.016. Epub 2006 Apr 24.
The present study emphasizes the important role of the immune reactions in the pathogenesis of Familial Mediterranean fever. In the present study, the total hemolytic activity of the complement and the activities of individual complement components, C1, C2, C3, and C4, were determined in the blood serum of 32 patients with FMF and 28 healthy subjects.
Hemolytic assay was applied, measuring THAC and individual complement components' activities. The patients were divided into 3 groups upon the regularity of colchicine therapy: patients receiving regular, irregular and not receiving colchicine treatment for at least 1 year.
No significant changes in the hemolytic activities of the C1, C2, C3, and C4 complement components were found between the healthy subjects and those FMF patients, who were receiving regular colchicine treatment.
Our data obtained have raised a number of important questions relevant to FMF pathogenesis and once again confirms the efficiency of regular colchicine treatment.
本研究强调免疫反应在家族性地中海热发病机制中的重要作用。在本研究中，测定了32例家族性地中海热患者和28名健康受试者血清中补体的总溶血活性以及单个补体成分C1、C2、C3和C4的活性。
采用溶血试验，测量总溶血活性和单个补体成分的活性。根据秋水仙碱治疗的规律性，将患者分为3组：接受规律治疗、不规律治疗以及至少1年未接受秋水仙碱治疗的患者。
在健康受试者和接受规律秋水仙碱治疗的家族性地中海热患者之间，未发现C1、C2、C3和C4补体成分的溶血活性有显著变化。
我们获得的数据提出了一些与家族性地中海热发病机制相关的重要问题，并再次证实了规律秋水仙碱治疗的有效性。
