狭叶山芝麻中的孕甾烷、香豆素和羽扇豆烷衍生物及细胞毒性成分。
Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia.
作者信息
Chen Wenliang, Tang Weidong, Lou Liguang, Zhao Weimin
机构信息
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Department of Natural Products Chemistry, 555 Zuchongzhi Road, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
出版信息
Phytochemistry. 2006 May;67(10):1041-7. doi: 10.1016/j.phytochem.2006.03.005. Epub 2006 Apr 24.
2alpha,7beta,20alpha-Trihydroxy-3beta,21-dimethoxy-5-pregnene (1), 6,7,9alpha-trihydroxy-3,8,11alpha-trimethylcyclohexo-[d,e]-coumarin (2), 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid (3), and 3beta-hydroxy-27-benzoyloxylup-20(29)-en-28-oic acid methyl ester (4), along with 24 known compounds were isolated and structurally characterized from roots and aerial parts of Helicteres angustifolia (Sterculiaceae). In a preliminary bioassay, the two cucurbitacin derivatives, cucurbitacin D and J exhibited significant inhibitory activities against the growth of both hepatocellular carcinoma BEL-7402 cells and malignant melanoma SK-MEL-28 cells in vitro.
从梧桐科植物狭叶山芝麻的根和地上部分分离得到了2α,7β,20α-三羟基-3β,21-二甲氧基-5-孕烯（1）、6,7,9α-三羟基-3,8,11α-三甲基环己并-[d,e]-香豆素（2）、3β-羟基-27-苯甲酰氧基羽扇豆-20(29)-烯-28-酸（3）和3β-羟基-27-苯甲酰氧基羽扇豆-20(29)-烯-28-酸甲酯（4），以及24个已知化合物，并对其进行了结构表征。在初步生物活性测试中，两种葫芦素衍生物葫芦素D和J在体外对肝癌BEL-7402细胞和恶性黑色素瘤SK-MEL-28细胞的生长均表现出显著的抑制活性。
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