Grande Nicola Maria, Plotino Gianluca, Falanga Alessandro, Pomponi Massimo, Somma Francesco
Department of Endodontics, Catholic University of Sacred Heart, Rome, Italy.
J Endod. 2006 May;32(5):460-4. doi: 10.1016/j.joen.2005.08.007.
Recent studies detected erosion of the dentinal walls following the use of EDTA as a final flush. Several authors have studied degradation of EDTA and it appears to be caused by an oxidation reaction. The objective of this paper was to verify through nuclear magnetic resonance (NMR) analysis if the oxidizing property of sodium hypochlorite inactivates EDTA. Solutions of sodium hypochlorite and EDTA were analyzed. EDTA tracing and the appearance of new signals indicative of by-products of the reaction, were studied at different time intervals with a NMR analysis. The tracings of NMR analysis confirmed that the reaction between sodium hypochlorite and EDTA lead to a very slow but progressive degradation of this compound. Mindful of the limitations of an in vitro study, the results of this study nevertheless demonstrated that a final flush with sodium hypochlorite cannot limit the chelating effects of EDTA in a clinically realistic time period.
近期研究发现，使用乙二胺四乙酸（EDTA）作为最终冲洗剂后，牙本质壁出现了侵蚀现象。几位作者对EDTA的降解进行了研究，发现其似乎是由氧化反应引起的。本文的目的是通过核磁共振（NMR）分析来验证次氯酸钠的氧化特性是否会使EDTA失活。对次氯酸钠和EDTA溶液进行了分析。利用NMR分析在不同时间间隔研究了EDTA的追踪情况以及表明反应副产物的新信号的出现情况。NMR分析的追踪结果证实，次氯酸钠与EDTA之间的反应导致该化合物非常缓慢但持续的降解。考虑到体外研究的局限性，本研究结果仍然表明，在临床实际时间段内，用次氯酸钠进行最终冲洗并不能限制EDTA的螯合作用。
