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评估呋喃妥因作为牙髓腔内药物的实验研究。

Assessment of Nitrofurantoin as an Experimental Intracanal Medicament in Endodontics.

机构信息

Conservative Department, College of Dentistry, University of Sulaimani, Sulaymaniyah, Kurdistan, Iraq.

Medical Pharmacology Department, College of Medicine, Hawler Medical University, Erbil, Kurdistan, Iraq.

出版信息

Biomed Res Int. 2020 Feb 18;2020:2128473. doi: 10.1155/2020/2128473. eCollection 2020.

DOI:10.1155/2020/2128473
PMID:32149086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7049449/
Abstract

UNLABELLED

. Multiple antibacterial agents have been mixed and used as an intracanal medicament-like modified triple antibiotic paste (MTAP) to eliminate (), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of ), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of . Three strains of ), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of = 90), group M (MTAP) ( = 90), group M (MTAP) ( = 90), group M (MTAP) (), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of = 90), group M (MTAP) ( = 90), group M (MTAP) ( = 90), group M (MTAP) (), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of.

RESULTS

Nit could eradicate S1, S2, and S3 completely with concentrations of 6.25, 12.5, and 25 mg/mL, respectively, while MTAP showed complete eradication of the three strains only at 25 mg/mL. In all the groups, it was found that the CFU counts of ), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of.

CONCLUSION

At the concentration of 25 mg/mL, the Nit paste is effective in eradicating completely when it is used as an intracanal medicament.), which has been most frequently identified in the cases of failed root canal treatment and periapical lesions. This study is aimed at using a single antibacterial agent, nitrofurantoin (Nit), as an experimental intracanal medicament paste against different clinical isolates of.

摘要

目的

使用单种抗菌剂呋喃妥因（Nit）作为实验性根管内药物糊剂，针对在根管治疗失败和根尖病变病例中最常发现的不同临床分离株，对抗 。

方法

选择 3 株 （S1、S2 和 S3）和 3 株 （M1、M2 和 M3），采用琼脂稀释法测定 Nit 和 MTAP 对 的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。将根管内分离株用 Nit 或 MTAP 处理，用菌落计数法检测抗菌药物对分离株的抗菌效果。

结果

Nit 对 S1、S2 和 S3 的 MIC 分别为 6.25、12.5 和 25 mg/mL，MBC 分别为 12.5、25 和 50 mg/mL。MTAP 对 3 株 （S1、S2 和 S3）的 MIC 和 MBC 均为 25 mg/mL。在所有实验组中，与对照组相比，Nit 和 MTAP 处理组的菌落计数明显减少（P<0.05）。

结论

浓度为 25 mg/mL 时，Nit 糊剂作为根管内药物，对 3 株临床分离株（S1、S2 和 S3）有较好的抗菌作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/b32504497f05/BMRI2020-2128473.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/879c0be94007/BMRI2020-2128473.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/6975414e679e/BMRI2020-2128473.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/b34b4b389d5e/BMRI2020-2128473.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/321a95fabbb8/BMRI2020-2128473.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/b32504497f05/BMRI2020-2128473.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/879c0be94007/BMRI2020-2128473.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/6975414e679e/BMRI2020-2128473.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/b34b4b389d5e/BMRI2020-2128473.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/321a95fabbb8/BMRI2020-2128473.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c79/7049449/b32504497f05/BMRI2020-2128473.005.jpg

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