Hauth Elke A M, Stockamp Christin, Maderwald Stefan, Mühler Andreas, Kimmig Rainer, Jaeger Horst, Barkhausen Jörg, Forsting Michael
Department of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Federal Republic of Germany.
Clin Imaging. 2006 May-Jun;30(3):160-5. doi: 10.1016/j.clinimag.2005.11.005.
To evaluate the three-time-point (3TP) method for diagnosis of breast lesions detected on contrast-enhanced MR mammography.
MR imaging was performed in 40 women with 120 suspected breast lesions in mammography and/or sonography. The contrast kinetics was converted by 3TP software on a pixel-by-pixel basis into color-coded images. Lesion diagnosis was made by analysis of color intensity and color hue. The 3TP results were compared with the results of the region-of-interest (ROI) method. In 16 patients, we were able to correlate the results with histopathological findings.
The 3TP method could successfully be performed in all MR mammographies. Forty (33%) lesions had a diameter of less than 5 mm, 56 (47%) lesions between 5 and 10 mm, and 24 (20%) lesions were greater than 1 cm. Of all 120 lesions, 65 (54%) showed heterogeneous contrast enhancement. In 117 (97%) of all 120 lesions the results of ROI and the automated 3TP method were considered equivalent. However, in three lesions the manual ROI differed from the 3TP method. After a second, repeated manual ROI placement, we were able to confirm equivalent results with the 3TP images as well.
The 3TP method automatically and reliably converts contrast kinetic information of the entire breast into a color-coded image. The 3TP method presents kinetic information of the entire dynamic series in an easy-to-interpret format and this automated method may allow to forego time-consuming and sometimes subjective manual ROI placements. This method displays the heterogeneity of the contrast enhancement pattern often observed in malignant lesions and makes it usable as diagnostic criterion.
评估在对比增强乳腺磁共振成像中检测到的乳腺病变的三点法（3TP）诊断方法。
对40名女性进行磁共振成像检查，这些女性在乳腺X线摄影和/或超声检查中有120处疑似乳腺病变。通过3TP软件逐像素地将对比动力学转换为彩色编码图像。通过分析颜色强度和色调进行病变诊断。将3TP结果与感兴趣区域（ROI）方法的结果进行比较。在16名患者中，我们能够将结果与组织病理学结果相关联。
3TP方法在所有乳腺磁共振成像中均能成功实施。40处（33%）病变直径小于5毫米，56处（47%）病变直径在5至10毫米之间，24处（20%）病变直径大于1厘米。在所有120处病变中，65处（54%）表现为不均匀对比增强。在所有120处病变中的117处（97%），ROI结果与自动3TP方法的结果被认为是等效的。然而，在三处病变中，手动ROI与3TP方法不同。在第二次重复进行手动ROI放置后，我们也能够确认与3TP图像的等效结果。
3TP方法能自动且可靠地将整个乳腺的对比动力学信息转换为彩色编码图像。3TP方法以易于解读的格式呈现整个动态序列的动力学信息，这种自动方法可能无需进行耗时且有时主观的手动ROI放置。该方法显示了在恶性病变中经常观察到的对比增强模式的异质性，并使其可用作诊断标准。
