Hauth E A M, Jaeger H, Maderwald S, Stockamp C, Mühler A, Kimmig R, Forsting M
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr 55, 45122 Essen, Germany.
Eur Radiol. 2006 Dec;16(12):2834-41. doi: 10.1007/s00330-006-0348-5. Epub 2006 Jul 29.
Our aim was to evaluate quantitative parametric analysis for characterization of breast lesions in contrast-enhanced magnetic resonance (MR) mammography. In 62 patients, contrast-enhanced MR mammography revealed 75 suspicious lesions, of which 18 were benign and 57 were malignant. The quantitative parametric analysis delineates signal intensity changes of contrast-enhanced lesions on a pixel-by-pixel basis. The initial rate of enhancement is coded by color intensity: a slow rate is coded to dark; a fast rate, bright. The postinitial enhancement change is coded by color hue: blue for increasing signal intensity, green for plateau, and red for decrease in signal intensity. Malignant lesions showed a significantly higher number of bright-red (P = 0.004) and medium-red (P < 0.001) pixels than benign lesions. Benign lesions showed significantly more blue pixels than did malignant lesions (P = 0.010). Of the 75 lesions, 72 (96%) showed heterogeneous distribution of pixel color hue. Quantitative parametric analysis of contrast kinetics in lesions can replace the subjective manual region of interest (ROI) method and makes a step toward standardization of MR mammography. It allows quantitative evaluation of different contrast kinetics parameters in contrast-enhanced breast lesions.
我们的目的是评估在对比增强磁共振（MR）乳腺摄影中对乳腺病变进行特征描述的定量参数分析。在62例患者中，对比增强MR乳腺摄影显示75个可疑病变，其中18个为良性，57个为恶性。定量参数分析在逐个像素的基础上描绘对比增强病变的信号强度变化。增强的初始速率由颜色强度编码：慢速编码为暗；快速编码为亮。初始增强后的变化由颜色色调编码：蓝色表示信号强度增加，绿色表示平台期，红色表示信号强度降低。恶性病变显示亮红色（P = 0.004）和中红色（P < 0.001）像素的数量明显多于良性病变。良性病变显示蓝色像素明显多于恶性病变（P = 0.010）。在75个病变中，72个（96%）显示像素色调的异质性分布。病变中对比动力学的定量参数分析可以取代主观的手动感兴趣区（ROI）方法，并朝着MR乳腺摄影的标准化迈出了一步。它允许对对比增强乳腺病变中的不同对比动力学参数进行定量评估。
