锌的吸收与钙的潴留：植酸盐的剂量依赖性抑制作用

Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate.

作者信息

Fredlund Kerstin, Isaksson Mats, Rossander-Hulthén Lena, Almgren Annette, Sandberg Ann-Sofie

机构信息

Department of Chemical and Biological Engineering/Food Science, Chalmers University of Technology, SE 412 96, Göteborg, Sweden.

出版信息

J Trace Elem Med Biol. 2006;20(1):49-57. doi: 10.1016/j.jtemb.2006.01.003. Epub 2006 Mar 2.

DOI:10.1016/j.jtemb.2006.01.003

PMID:16632176

Abstract

The dose-dependent inhibitory effect of sodium phytate (myo-inositol-hexaphosphate) on absorption of zinc and retention of calcium was studied in man. No systematic study of this dose-response effect has been reported to this time. Forty subjects were served meals containing white wheat rolls without/with additions of phytate. Ten subjects were given test meals containing one or two of the studied levels of phytate and in addition all subjects were served meals to which no phytate was added. The zinc content was 3.1 mg (47 micromol) and the calcium content 266 mg (6.6 mmol). The rolls were labelled extrinsically with radioisotopes, 65Zn and 47Ca, and whole-body retention of both minerals was measured. Totally 105 meals were served, 36 meals in which no phytate was added and 9-10 meals on each level of phytate. The zinc absorption in meals to which either 0, 25, 50, 75, 100, 140, 175 or 250 mg of phytate-P (0, 134, 269, 403, 538, 753, 941 or 1344 micromol phytate) had been added was 22%, 16%, 14%, 11%, 7%, 7%, 7% and 6%, respectively (mean values). The addition of 50 mg phytate-P or more significantly decreased zinc absorption (p=0.01) as compared to absorption from the test meals with no added phytate. The calcium retention at day 7 in the same meals was 31%, 28%, 27%, 26%, 22%, 19%, 14% and 11% (mean values). The addition of 100 mg phytate-P or more significantly decreased calcium retention (p=0.03) compared to the test meals with no added phytate. It was concluded that the inhibitory effect of phytate on the absorption of zinc and the retention of calcium was dose dependent.

摘要

在人体中研究了植酸钠（肌醇六磷酸）对锌吸收和钙潴留的剂量依赖性抑制作用。此前尚未有关于这种剂量反应效应的系统性研究报告。40名受试者食用了添加或未添加植酸盐的白面包卷餐食。10名受试者食用了含有一或两个研究水平植酸盐的测试餐，此外所有受试者还食用了未添加植酸盐的餐食。锌含量为3.1毫克（47微摩尔），钙含量为266毫克（6.6毫摩尔）。面包卷用放射性同位素65Zn和47Ca进行外部标记，并测量两种矿物质的全身潴留情况。总共提供了105餐，其中36餐未添加植酸盐，每个植酸盐水平提供9 - 10餐。添加了0、25、50、75、100、140、175或250毫克植酸盐 - P（0、134、269、403、538、753、941或1344微摩尔植酸盐）的餐食中锌的吸收分别为22%、16%、14%、11%、7%、7%、7%和6%（平均值）。与未添加植酸盐的测试餐相比，添加50毫克或更多植酸盐 - P显著降低了锌的吸收（p = 0.01）。相同餐食在第7天的钙潴留分别为31%、28%、27%、26%、22%、19%、14%和11%（平均值）。与未添加植酸盐的测试餐相比，添加100毫克或更多植酸盐 - P显著降低了钙潴留（p = 0.03）。得出的结论是，植酸盐对锌吸收和钙潴留的抑制作用是剂量依赖性的。