Eggermont Alexander M M
Erasmus Medical Center, Daniel den Hoed Cancer Center, 301 Groene Hilledijk, EA 3075, Rotterdam, the Netherlands.
Surg Oncol Clin N Am. 2006 Apr;15(2):439-51. doi: 10.1016/j.soc.2005.12.001.
No effective therapy for metastatic melanoma exists. Polychemotherapy or chemoimmunotherapy have not shown survival benefits. Vaccines have shown little activity in stage IV disease. To advance the identification of effective agents, new drugs can and should be offered as first-line treatment. Efforts must be made to improve understanding of the biology of malignant melanoma. Too many phase III trials have been conducted with a poor understanding of the mechanism of action of the involved drugs.
目前尚无针对转移性黑色素瘤的有效疗法。多药化疗或化疗免疫疗法尚未显示出生存获益。疫苗在IV期疾病中几乎没有活性。为了推进有效药物的识别，新药可以且应该作为一线治疗提供。必须努力提高对恶性黑色素瘤生物学的理解。太多的III期试验在对所涉药物作用机制了解不足的情况下进行。
