Antoniades Demetrios Z, Markopoulos Anastasios K, Andreadis Demetrios, Balaskas Ilias, Patrikalou Eva, Grekas Demetrios
School of Dentistry, Aristotle University of Thessaloniki, Greece.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 May;101(5):608-13. doi: 10.1016/j.tripleo.2005.08.006. Epub 2006 Feb 17.
Uremic stomatitis represents a relatively uncommon intraoral complication seen, mostly, in cases of end-stage renal disease or undiagnosed/untreated chronic renal failure. Its incidence has decreased due to the advent of renal dialysis. Clinically uremic stomatitis is characterized by the presence of painful plaques and crusts that are usually distributed on the buccal mucosa, dorsal or ventral surface of the tongue, gingiva, lips, and floor of the mouth. Treatment consists of improvement of urea blood concentration and the underlying renal failure, supported by increased oral hygiene with antiseptic mouthwashes and antimicrobial/antifungal agents if necessary. Although uremic stomatitis occurs in patients with end-stage renal disease, we report a case of a patient who exhibited an ulcerative form of uremic stomatitis related to the sudden relapse of uremia, although not in an advanced stage of her renal disease. A description of the clinical and microscopic appearance is given along with our hypothesis for the pathogenesis of the disease.
尿毒症性口炎是一种相对罕见的口腔内并发症，主要见于终末期肾病或未诊断/未治疗的慢性肾衰竭病例。由于肾透析的出现，其发病率已有所下降。临床上，尿毒症性口炎的特征是出现疼痛性斑块和痂皮，通常分布在颊黏膜、舌背或舌腹面、牙龈、嘴唇及口腔底部。治疗包括改善血尿素浓度和潜在的肾衰竭，必要时通过使用抗菌漱口水及抗菌/抗真菌药物加强口腔卫生来辅助治疗。尽管尿毒症性口炎发生于终末期肾病患者，但我们报告了一例患者，其表现为与尿毒症突然复发相关的溃疡性尿毒症性口炎，尽管其肾病尚未处于晚期。本文给出了该疾病的临床和显微镜下表现描述以及我们对其发病机制的假说。
